METHODS AND COMPOSITIONS FOR TREATMENT OF SARS-COV-2 INFECTION
Inventors collect and analyze the blood of patients to determine their cytokine profile in the serum and the profile/activation status of circulating leukocytes by flow cytometry and measure inflammasomes activation using the FAM-FLICA probe that labels activated caspase-1 (that processes pro-IL-1β in mature IL-1β). Moreover, inventors describes that a use of a specific NLRP3 inhibitor (MCC950) allows them to determine that the activation observed in the blood samples is NLRP3 dependent. Accordingly, the invention relates to NLRP3 inhibitors for use in the treatment of SARS-CoV-2 infection and SARS-CoV-2 related disorders in a subject in need thereof..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 07. Okt. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
BOYER LAURENT [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-10-07, Last update posted on www.tib.eu: 2022-09-06, Last updated: 2023-02-09 |
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| Patentnummer: |
WO2021198511 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA013454331 |
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| 520 | |a Inventors collect and analyze the blood of patients to determine their cytokine profile in the serum and the profile/activation status of circulating leukocytes by flow cytometry and measure inflammasomes activation using the FAM-FLICA probe that labels activated caspase-1 (that processes pro-IL-1β in mature IL-1β). Moreover, inventors describes that a use of a specific NLRP3 inhibitor (MCC950) allows them to determine that the activation observed in the blood samples is NLRP3 dependent. Accordingly, the invention relates to NLRP3 inhibitors for use in the treatment of SARS-CoV-2 infection and SARS-CoV-2 related disorders in a subject in need thereof. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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