COLD-ADAPTED ATTENUATION DONOR, STRAIN OF INFLUENZA VIRUS B/SSSR/60/69/5252, INTENDED FOR PRODUCTION OF STRAINS OF LIVE INTRANASAL INFLUENZA VACCINE
FIELD: medicine; biotechnology.SUBSTANCE: invention relates to medical virology and biotechnology. Described is an influenza strain B/SSSR/60/69/5252, obtained as result of 3-fold cloning in developing chicken embryos of a known attenuation donor B/SSSR/60/69. Strain actively propagates in chicken embryos at optimum temperature of 32 °C, is characterized by genetic homogeneity, temperature sensitivity and cold adaptation of reproduction, stability of properties and harmlessness and attenuation for laboratory animals.EFFECT: use of a pure line of attenuation donor B/SSSR/ 60/69/5252 for reassortment with regularly updated epidemic influenza viruses allows to guarantee stability of characteristics of attenuated strains for live influenza vaccine in accordance with Pharmacopoeia Monograph FSP 42-0417-4097-03 for a live influenza vaccine for intranasal use and can be used in the production of a live influenza intranasal cold-adapted attenuated reassortant vaccine for adults and children.1 cl, 8 tbl, 6 ex.
| Medienart: |
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 04. Apr. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
RUDENKO LARISA GEORGIEVNA [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-04-04, Last update posted on www.tib.eu: 2022-09-04, Last updated: 2023-02-09 |
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| Patentnummer: |
RU2769672 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA013429493 |
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| 245 | 1 | 0 | |a COLD-ADAPTED ATTENUATION DONOR, STRAIN OF INFLUENZA VIRUS B/SSSR/60/69/5252, INTENDED FOR PRODUCTION OF STRAINS OF LIVE INTRANASAL INFLUENZA VACCINE |
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| 520 | |a FIELD: medicine; biotechnology.SUBSTANCE: invention relates to medical virology and biotechnology. Described is an influenza strain B/SSSR/60/69/5252, obtained as result of 3-fold cloning in developing chicken embryos of a known attenuation donor B/SSSR/60/69. Strain actively propagates in chicken embryos at optimum temperature of 32 °C, is characterized by genetic homogeneity, temperature sensitivity and cold adaptation of reproduction, stability of properties and harmlessness and attenuation for laboratory animals.EFFECT: use of a pure line of attenuation donor B/SSSR/ 60/69/5252 for reassortment with regularly updated epidemic influenza viruses allows to guarantee stability of characteristics of attenuated strains for live influenza vaccine in accordance with Pharmacopoeia Monograph FSP 42-0417-4097-03 for a live influenza vaccine for intranasal use and can be used in the production of a live influenza intranasal cold-adapted attenuated reassortant vaccine for adults and children.1 cl, 8 tbl, 6 ex | ||
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