Polyclonal antibodies produced using HIV-1 trimeric envelope glycoprotein subunits
Polyclonal Antibodies produced using HIV-1 Trimeric Envelope Glycoprotein Subunits (TEGS) are provided. TEGS are comprised of non-infectious complexes comprising a trimeric envelope glycoprotein subunit comprising gp120 bound to membrane-anchored trimeric native gp41. The gp120 and gp41 present in the TEGS are not chemically fixed or cross-linked. Immunization with the TEGS elicits polyclonal antibodies that neutralize diverse viruses in HIV infection assay using peripheral blood mononuclear cells (PBMCs). The present invention relates to a method for reducing the occurrence and/or severity of HIV infections..
Medienart: |
Patent |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Europäisches Patentamt - (2022) vom: 08. März Zur Gesamtaufnahme - year:2022 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
KILLIAN M SCOTT [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-03-08, Last update posted on www.tib.eu: 2022-08-10, Last updated: 2023-02-09 |
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Patentnummer: |
US11267872 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA012940046 |
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520 | |a Polyclonal Antibodies produced using HIV-1 Trimeric Envelope Glycoprotein Subunits (TEGS) are provided. TEGS are comprised of non-infectious complexes comprising a trimeric envelope glycoprotein subunit comprising gp120 bound to membrane-anchored trimeric native gp41. The gp120 and gp41 present in the TEGS are not chemically fixed or cross-linked. Immunization with the TEGS elicits polyclonal antibodies that neutralize diverse viruses in HIV infection assay using peripheral blood mononuclear cells (PBMCs). The present invention relates to a method for reducing the occurrence and/or severity of HIV infections. | ||
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