METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES
The invention relates to a pan caspase inhibitor for use in the treatment of lung infection (such as Syndrome-Corona Virus (SARS-CoV) infection and SARS-COV related disorders) in a subject in need thereof. The current COVID-19 pandemic is predicted to last several additional months, further increasing mortality rates, especially in the more fragile populations. Inventors have surprisingly found that Emricasan is able to efficiently inhibit caspase-8 which is involved in the inflammation process. More particularly, inventors have shown that Emricasan blocks caspase-1 activation in monocytes from healthy donor or COVID19 patient. This new finding with either Emricasan alone or in combination with other therapeutics seem to be very promising in patients suffering from an infectious disease, more particularly an infection caused by Syndrome-Corona Virus..
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Patent| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Europäisches Patentamt - (2022) vom: 13. Jan. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
AUBERGER PATRICK [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2022-01-13, Last update posted on www.tib.eu: 2022-07-20, Last updated: 2023-02-09 |
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| Patentnummer: |
WO2022008597 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a The invention relates to a pan caspase inhibitor for use in the treatment of lung infection (such as Syndrome-Corona Virus (SARS-CoV) infection and SARS-COV related disorders) in a subject in need thereof. The current COVID-19 pandemic is predicted to last several additional months, further increasing mortality rates, especially in the more fragile populations. Inventors have surprisingly found that Emricasan is able to efficiently inhibit caspase-8 which is involved in the inflammation process. More particularly, inventors have shown that Emricasan blocks caspase-1 activation in monocytes from healthy donor or COVID19 patient. This new finding with either Emricasan alone or in combination with other therapeutics seem to be very promising in patients suffering from an infectious disease, more particularly an infection caused by Syndrome-Corona Virus. | ||
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