一种GP73抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用
本发明实施例涉及一种GP73抑制剂在制备治疗SARS‑CoV‑2肺炎及其并发症的药物中的应用。本发明实施例中发明人发现胆固醇能促进ACE2在细胞膜表面富集，同时GP73参与胆固醇促进的ACE2在细胞膜的富集以及参与胆固醇促进的SARS‑CoV‑2病毒入侵。发明人还通过细胞实验证明了：GP73抑制剂能够降低ACE2在细胞膜的富集并阻止SARS‑CoV‑2病毒入侵，从而可以达到治疗SARS‑CoV‑2肺炎及其并发症的效果。.
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 14. Dez. Zur Gesamtaufnahme - year:2021 |
|---|
| Sprache: |
Chinesisch |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-12-14, Last update posted on www.tib.eu: 2022-07-13, Last updated: 2023-02-09 |
|---|
| Patentnummer: |
CN113144194 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA012624551 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA012624551 | ||
| 003 | DE-627 | ||
| 005 | 20230503194431.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230215s2021 xx |||||o 00| ||chi c | ||
| 035 | |a (DE-627)EPA012624551 | ||
| 035 | |a (EPA)CN113144194 | ||
| 035 | |a (EPA)76882703 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a chi | ||
| 245 | 1 | 0 | |a 一种GP73抑制剂在制备治疗SARS-CoV-2肺炎及其并发症的药物中的应用 |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2021-12-14, Last update posted on www.tib.eu: 2022-07-13, Last updated: 2023-02-09 | ||
| 520 | |a 本发明实施例涉及一种GP73抑制剂在制备治疗SARS‑CoV‑2肺炎及其并发症的药物中的应用。本发明实施例中发明人发现胆固醇能促进ACE2在细胞膜表面富集，同时GP73参与胆固醇促进的ACE2在细胞膜的富集以及参与胆固醇促进的SARS‑CoV‑2病毒入侵。发明人还通过细胞实验证明了：GP73抑制剂能够降低ACE2在细胞膜的富集并阻止SARS‑CoV‑2病毒入侵，从而可以达到治疗SARS‑CoV‑2肺炎及其并发症的效果。 | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a 615 | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2021) vom: 14. Dez. |
| 773 | 1 | 8 | |g year:2021 |g day:14 |g month:12 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/76882703/publication/CN113144194A1?q=CN113144194 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | u | w | |j 2021 |b 14 |c 12 |
| 951 | |a AR | ||
| 952 | |j 2021 |b 14 |c 12 | ||