TRIARYLPYRIDINE COMPOUNDS AND USE THEREOF FOR TREATING CANCER
The invention relates to new bis-triazole 2,4,6-triarylpyridines compounds and their use in the field of oncology, in particular in the prevention and/or treatment of cancer disease. The inventors have observed that the new bis-triazole 2,4,6-triarylpyridines were able to induce cancer cells death either as a standalone or, synergistically, in combination with a lysosomotropic agent, such as chloroquine. The compounds were active against a variety of cancer cells such as HeLa (cervical cancer cell), A549 (lung carcinoma), and PDX-2 or PDX-3 (lung adenocarcinoma). The invention also relates to compositions and methods for prevention and/or treatment of cancer diseases using the new bis-triazole 2,4,6-triarylpyridines compounds..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Europäisches Patentamt - (2021) vom: 02. Dez. Zur Gesamtaufnahme - year:2021 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
BEAUVARLET JENNIFER [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-12-02, Last update posted on www.tib.eu: 2023-07-19, Last updated: 2023-07-28 |
---|
Patentnummer: |
WO2021239976 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA012582778 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA012582778 | ||
003 | DE-627 | ||
005 | 20230728090458.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230215s2021 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)EPA012582778 | ||
035 | |a (EPA)WO2021239976 | ||
035 | |a (EPA)71575252 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a BEAUVARLET JENNIFER |e verfasserin |4 aut | |
245 | 1 | 0 | |a TRIARYLPYRIDINE COMPOUNDS AND USE THEREOF FOR TREATING CANCER |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), First posted: 2021-12-02, Last update posted on www.tib.eu: 2023-07-19, Last updated: 2023-07-28 | ||
520 | |a The invention relates to new bis-triazole 2,4,6-triarylpyridines compounds and their use in the field of oncology, in particular in the prevention and/or treatment of cancer disease. The inventors have observed that the new bis-triazole 2,4,6-triarylpyridines were able to induce cancer cells death either as a standalone or, synergistically, in combination with a lysosomotropic agent, such as chloroquine. The compounds were active against a variety of cancer cells such as HeLa (cervical cancer cell), A549 (lung carcinoma), and PDX-2 or PDX-3 (lung adenocarcinoma). The invention also relates to compositions and methods for prevention and/or treatment of cancer diseases using the new bis-triazole 2,4,6-triarylpyridines compounds. | ||
650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
650 | 4 | |a che | |
650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
650 | 4 | |a 615 | |
700 | 0 | |a DJAVAHERI-MERGNY MOJGAN |4 aut | |
700 | 0 | |a RABINDRA NATH DAS |4 aut | |
700 | 0 | |a MERGNY JEAN-LOUIS |4 aut | |
700 | 0 | |a GUILLON JEAN |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2021) vom: 02. Dez. |
773 | 1 | 8 | |g year:2021 |g day:02 |g month:12 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/71575252/publication/WO2021239976A1?q=WO2021239976 |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
936 | u | w | |j 2021 |b 02 |c 12 |
951 | |a AR | ||
952 | |j 2021 |b 02 |c 12 |