Construction method of persistent gouty arthritis animal disease model
The invention provides a construction method of a persistent gouty arthritis animal disease model. The method comprises the following steps: embedding an MSU crystal in an articular cavity for 3-5 times at an interval of 3-5 days; and before an MSU crystal is embedded in an articular cavity, damaging femoral intercondylar fossa cartilage to cause cartilage defects. According to the method, the MSU embedding mode and frequency are redesigned, the pathophysiological process of recurrent gout attack is simulated by adopting repeated intervention measures of sufficient MSU, the operation is simple and repeatable, complications such as incision-related infection and MSU leakage are avoided, a producible, economical and accurate model is provided for in-vivo research of MSU deposition and local structure erosion in gouty arthritis, and a good research platform is further provided for research of related diseases..
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 10. Aug. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
XU HANLIN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-08-10, Last update posted on www.tib.eu: 2022-04-11, Last updated: 2023-02-09 |
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| Patentnummer: |
CN113230260 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA012210838 |
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| 520 | |a The invention provides a construction method of a persistent gouty arthritis animal disease model. The method comprises the following steps: embedding an MSU crystal in an articular cavity for 3-5 times at an interval of 3-5 days; and before an MSU crystal is embedded in an articular cavity, damaging femoral intercondylar fossa cartilage to cause cartilage defects. According to the method, the MSU embedding mode and frequency are redesigned, the pathophysiological process of recurrent gout attack is simulated by adopting repeated intervention measures of sufficient MSU, the operation is simple and repeatable, complications such as incision-related infection and MSU leakage are avoided, a producible, economical and accurate model is provided for in-vivo research of MSU deposition and local structure erosion in gouty arthritis, and a good research platform is further provided for research of related diseases. | ||
| 650 | 4 | |a A01K: Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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