Application of R848 in preparation of medicine for inhibiting novel coronavirus SARS-CoV-2
The invention belongs to the field of biological agents, and discloses application of R848 in preparation of a medicine for inhibiting novel coronavirus SARS-CoV-2, an applicant finds that R848 has asmall toxic effect on Caco-2 cells through an in vitro cell test and a mouse test, infection of the Caco2 cells by the SARS-CoV-2 can be remarkably inhibited at the in vitro cell level, and proliferation of the Caco-2 cells is inhibited. The characteristics of safety and high efficiency are realized; meanwhile, by constructing a mouse SARS-CoV-2 infection model, it is found that R848 can significantly reduce the weight loss degree of the mouse, reduce the virus content in the lung tissue of the mouse and improve the survival rate of the mouse, so that R848 has very large clinical treatment potential..
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Patent| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Europäisches Patentamt - (2020) vom: 29. Dez. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
JIN MEILIN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-12-29, Last update posted on www.tib.eu: 2022-04-10, Last updated: 2023-02-09 |
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| Patentnummer: |
CN112138006 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA011480564 |
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| 520 | |a The invention belongs to the field of biological agents, and discloses application of R848 in preparation of a medicine for inhibiting novel coronavirus SARS-CoV-2, an applicant finds that R848 has asmall toxic effect on Caco-2 cells through an in vitro cell test and a mouse test, infection of the Caco2 cells by the SARS-CoV-2 can be remarkably inhibited at the in vitro cell level, and proliferation of the Caco-2 cells is inhibited. The characteristics of safety and high efficiency are realized; meanwhile, by constructing a mouse SARS-CoV-2 infection model, it is found that R848 can significantly reduce the weight loss degree of the mouse, reduce the virus content in the lung tissue of the mouse and improve the survival rate of the mouse, so that R848 has very large clinical treatment potential. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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