DIAGNOSTIC METHOD AND THERAPY
The invention relates to a method of identifying patients who are positive for CASPR2 autoantibodies which are predicted to respond to immunotherapy, the method comprising i) obtaining a sample from a subject having autoantibodies against CASPR2; and ii) screening for the presence of the allele HLA DRB1*11:01. The invention also relates to one or more novel isolated peptides, wherein the peptide comprises the sequence of any of Seq ID no: 1 to Seq ID no: 57 or a sequence having at least 80%, 85%, 90%, 95% or more sequence identity with one of Seq ID no 1 to 7, preferably with one of Seq ID no 40 to 57..
| Medienart: |
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Patent| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Europäisches Patentamt - (2021) vom: 11. März Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
IRANI SAROSH R [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-03-11, Last update posted on www.tib.eu: 2022-06-24, Last updated: 2023-02-09 |
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| Patentnummer: |
US2021071249 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The invention relates to a method of identifying patients who are positive for CASPR2 autoantibodies which are predicted to respond to immunotherapy, the method comprising i) obtaining a sample from a subject having autoantibodies against CASPR2; and ii) screening for the presence of the allele HLA DRB1*11:01. The invention also relates to one or more novel isolated peptides, wherein the peptide comprises the sequence of any of Seq ID no: 1 to Seq ID no: 57 or a sequence having at least 80%, 85%, 90%, 95% or more sequence identity with one of Seq ID no 1 to 7, preferably with one of Seq ID no 40 to 57. | ||
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| 650 | 4 | |a bio | |
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