HEMOSTIMULATING AGENT
FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to pharmacology and hematology. Use of the JNK inhibitor (c-Jun N-terminal kinase) as a hemostimulating agent under conditions of cytostatic myelosuppression has been proposed. JNK IQ-IS and SP600125 inhibitors up to 238.2 % and up to 250.2 %, respectively, increased the content of mature neutrophil granulocytes in the bone marrow of mice after cytostatic myelosuppression caused by 5-FU, also increased the erythroid cells content.EFFECT: invention provides an expansion of the arsenal of highly effective hemostimulating agents.1 cl, 3 tbl, 1 ex.
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Patent| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Europäisches Patentamt - (2018) vom: 19. März Zur Gesamtaufnahme - year:2018 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZYUZKOV GLEB NIKOLAEVICH [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2018-03-19, Last update posted on www.tib.eu: 2022-05-31, Last updated: 2023-02-09 |
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| Patentnummer: |
RU2647833 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA009897097 |
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| 520 | |a FIELD: medicine.SUBSTANCE: invention relates to medicine, specifically to pharmacology and hematology. Use of the JNK inhibitor (c-Jun N-terminal kinase) as a hemostimulating agent under conditions of cytostatic myelosuppression has been proposed. JNK IQ-IS and SP600125 inhibitors up to 238.2 % and up to 250.2 %, respectively, increased the content of mature neutrophil granulocytes in the bone marrow of mice after cytostatic myelosuppression caused by 5-FU, also increased the erythroid cells content.EFFECT: invention provides an expansion of the arsenal of highly effective hemostimulating agents.1 cl, 3 tbl, 1 ex | ||
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