NOVEL HUMANIZED ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR, ITS NUCELIC ACID SEQUENCE AND ITS PREPARATION
The present invention relates to novel humanized anti-CD19chimeric antigen receptor containing an optimized anti-CD19 binding domain effective against the treatment of disease associated with expression of the Cluster of Differentiation 19 protein (CD19), and to a nucleic acid molecule encoding the humanized CAR. The invention also encompasses a process for the preparation of the CAR, composition containing the CAR, vectors containing the polynucleotide encoding the CAR and cells expressing the CAR at their surface, in particular for their use in immunotherapy..
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Patent| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Europäisches Patentamt - (2019) vom: 22. Aug. Zur Gesamtaufnahme - year:2019 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
PURWAR RAHUL [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2019-08-22, Last update posted on www.tib.eu: 2024-03-06, Last updated: 2024-03-08 |
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| Patentnummer: |
WO2019159193 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA009052488 |
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| 520 | |a The present invention relates to novel humanized anti-CD19chimeric antigen receptor containing an optimized anti-CD19 binding domain effective against the treatment of disease associated with expression of the Cluster of Differentiation 19 protein (CD19), and to a nucleic acid molecule encoding the humanized CAR. The invention also encompasses a process for the preparation of the CAR, composition containing the CAR, vectors containing the polynucleotide encoding the CAR and cells expressing the CAR at their surface, in particular for their use in immunotherapy. | ||
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