MICROFLUIDIC SYSTEM HAVING MONOLITHIC NANOPLASMONIC STRUCTURES
A microfluidic system, particularly suited as a cell culture system, is provided having a single monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements required for plasmonic response monitoring and a network of microchannels for precisely controlling cellular environment. The system has the additional advantages of low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, amenability to mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques. A ratio of greater than 0.2 between the cross-sectional dimension and the spacing distance of the nano-scale elements is useful for plasmonic response monitoring. A process for producing such a system involves fabrication of a master mold containing the nano-scale elements etched into a hard substrate, and the micro-scale and meso-scale features, such as channels and chambers, provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold and then the features of the intended device transferred to a polymeric substrate using the stamp..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Europäisches Patentamt - (2020) vom: 24. März Zur Gesamtaufnahme - year:2020 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
MALIC LIDIJA [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-03-24, Last update posted on www.tib.eu: 2023-12-25, Last updated: 2023-12-29 |
---|
Patentnummer: |
CA2830103 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA008142165 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA008142165 | ||
003 | DE-627 | ||
005 | 20231229104807.0 | ||
007 | cr uuu---uuuuu | ||
008 | 210531s2020 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)EPA008142165 | ||
035 | |a (EPA)CA2830103 | ||
035 | |a (EPA)46829979 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a MALIC LIDIJA |e verfasserin |4 aut | |
245 | 1 | 0 | |a MICROFLUIDIC SYSTEM HAVING MONOLITHIC NANOPLASMONIC STRUCTURES |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), First posted: 2020-03-24, Last update posted on www.tib.eu: 2023-12-25, Last updated: 2023-12-29 | ||
520 | |a A microfluidic system, particularly suited as a cell culture system, is provided having a single monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements required for plasmonic response monitoring and a network of microchannels for precisely controlling cellular environment. The system has the additional advantages of low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, amenability to mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques. A ratio of greater than 0.2 between the cross-sectional dimension and the spacing distance of the nano-scale elements is useful for plasmonic response monitoring. A process for producing such a system involves fabrication of a master mold containing the nano-scale elements etched into a hard substrate, and the micro-scale and meso-scale features, such as channels and chambers, provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold and then the features of the intended device transferred to a polymeric substrate using the stamp. | ||
650 | 4 | |a B21D: Working or processing of sheet metal or metal tubes, rods or profiles without essentially removing material; punching metal (working or processing of wire b21f) | |
650 | 4 | |a C12M: Apparatus for enzymology or microbiology (installations for fermenting manure a01c0003020000;preservation of living parts of humans or animals a01n0001020000;brewing apparatus c12c;fermentation apparatus for wine c12g;apparatus for preparing vinegar c12j0001100000) | |
650 | 4 | |a G01N: Investigating or analysing materials by determining their chemical or physical properties (measuring or testing processes other than immunoassay, involving enzymes or microorganisms c12m, c12q) | |
650 | 4 | |a phy | |
650 | 4 | |a C08J: Working-up; general processes of compounding; after-treatment not covered by subclasses c08b, c08c, c08f, c08g or c08h (working, e.g. shaping, of plastics b29) | |
650 | 4 | |a cet | |
650 | 4 | |a bio | |
650 | 4 | |a mas | |
650 | 4 | |a B29C: Shaping or joining of plastics; shaping of material in a plastic state, not otherwise provided for; after-treatment of the shaped products, e.g. repairing (making preforms b29b0011000000; making laminated products by combining previously unconnected layers which become one product whose layers will remain together b32b0037000000-b32b0041000000) | |
650 | 4 | |a B22C: Foundry moulding (moulding refractory materials in general b28b) | |
650 | 4 | |a B81C: Processes or apparatus specially adapted for the manufacture or treatment of microstructural devices or systems (making microcapsules or microballoons b01j0013020000;processes or apparatus specially adapted for the manufacture or treatment of piezo-electric, electrostrictive or magnetostrictive elements per seh01l0041220000) | |
650 | 4 | |a che | |
650 | 4 | |a B82Y: Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | |
650 | 4 | |a 615 | |
700 | 0 | |a MORTON KEITH |4 aut | |
700 | 0 | |a VERES TEODOR |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2020) vom: 24. März |
773 | 1 | 8 | |g year:2020 |g day:24 |g month:03 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/46829979/publication/CA2830103A1?q=CA2830103 |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
936 | u | w | |j 2020 |b 24 |c 03 |
951 | |a AR | ||
952 | |j 2020 |b 24 |c 03 |