Preparation method of chlorobenzothiazepine compound, product prepared by preparation method and application of product
The invention discloses a preparation method of a chlorobenzothiazepine compound, a product prepared by the preparation method and application of the chlorobenzothiazepine compound, and relates to thetechnical field of chemical synthesis. The preparation method of the chlorobenzothiazepine compound comprises the following steps of: carrying out thiolation, aldehyde amine condensation, amine-carbon addition, amino protection, oxidation, amino deprotection and the like on 2-chloro-6-fluorine-benzaldehyde as an initial raw material to obtain a chlorobenzothiazepine compound product of 6-chloro-2, 3, 4, 5-tetrahydro-1, 4-benzothiazepine-1, 1-dioxide. The preparation method of the chlorobenzothiazepine compound has the advantage that a chlorine element can be easily introduced. The chlorobenzothiazepine compound product has the advantage that the application range of the product can be expanded to a certain extent..
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Patent| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Europäisches Patentamt - (2020) vom: 04. Sept. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
SHAN YUQING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
615 |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-09-04, Last update posted on www.tib.eu: 2022-04-09, Last updated: 2023-02-09 |
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| Patentnummer: |
CN111620838 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA006543197 |
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| 520 | |a The invention discloses a preparation method of a chlorobenzothiazepine compound, a product prepared by the preparation method and application of the chlorobenzothiazepine compound, and relates to thetechnical field of chemical synthesis. The preparation method of the chlorobenzothiazepine compound comprises the following steps of: carrying out thiolation, aldehyde amine condensation, amine-carbon addition, amino protection, oxidation, amino deprotection and the like on 2-chloro-6-fluorine-benzaldehyde as an initial raw material to obtain a chlorobenzothiazepine compound product of 6-chloro-2, 3, 4, 5-tetrahydro-1, 4-benzothiazepine-1, 1-dioxide. The preparation method of the chlorobenzothiazepine compound has the advantage that a chlorine element can be easily introduced. The chlorobenzothiazepine compound product has the advantage that the application range of the product can be expanded to a certain extent. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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