NOVEL COMPOUND OF STEROCALPIN A FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS
PURPOSE: A composition for the prevention and treatment of arteriosclerosis containing a novel compound of stereocalpin-A is provided to suppress the expression of VCAM-1 and ICAM-1 induced by TNF-alpha due to the incapability of signal transduction to MAP kinse, Akt, and NF-kB by the suppression of the ROS production. CONSTITUTION: A pharmaceutical composition for the prevention and treatment of arteriosclerosis comprises stereocalpin-A represented by chemical formula 1 as an active ingredient. The stereocalpin-A represented by the chemical formula 1 is contained at 0.01-10 parts by weight based on 100 parts by weight of composition. The stereocalpin-A represented by chemical formula 1 suppresses the expression of cell adhesion molecules which induces the TNF-alpha. The cell adhesion molecules are ICAM-1 or VCAM-1. The stereocalpin-A is originated from Ramalina terebrata..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2018 |
---|---|
Erschienen: |
2018 |
Enthalten in: |
Europäisches Patentamt - (2018) vom: 27. Sept. Zur Gesamtaufnahme - year:2018 |
---|
Sprache: |
Unbestimmt |
---|
Beteiligte Personen: |
YIM JOUNG HAN [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Themen: |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), Last update posted on www.epo.org: 2018-09-27, Last updated: 2021-03-11 |
---|
Patentnummer: |
KR20130043995 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA00647246X |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA00647246X | ||
003 | DE-627 | ||
005 | 20230504122409.0 | ||
007 | cr uuu---uuuuu | ||
008 | 210531s2018 xx |||||o 00| ||und c | ||
035 | |a (DE-627)EPA00647246X | ||
035 | |a (EPA)KR20130043995 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a und | ||
100 | 0 | |a YIM JOUNG HAN |e verfasserin |4 aut | |
245 | 1 | 0 | |a NOVEL COMPOUND OF STEROCALPIN A FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), Last update posted on www.epo.org: 2018-09-27, Last updated: 2021-03-11 | ||
520 | |a PURPOSE: A composition for the prevention and treatment of arteriosclerosis containing a novel compound of stereocalpin-A is provided to suppress the expression of VCAM-1 and ICAM-1 induced by TNF-alpha due to the incapability of signal transduction to MAP kinse, Akt, and NF-kB by the suppression of the ROS production. CONSTITUTION: A pharmaceutical composition for the prevention and treatment of arteriosclerosis comprises stereocalpin-A represented by chemical formula 1 as an active ingredient. The stereocalpin-A represented by the chemical formula 1 is contained at 0.01-10 parts by weight based on 100 parts by weight of composition. The stereocalpin-A represented by chemical formula 1 suppresses the expression of cell adhesion molecules which induces the TNF-alpha. The cell adhesion molecules are ICAM-1 or VCAM-1. The stereocalpin-A is originated from Ramalina terebrata. | ||
650 | 4 | |a A61K | |
650 | 4 | |a che | |
650 | 4 | |a A61P | |
650 | 4 | |a 615 | |
700 | 0 | |a KIM IL CHAN |e verfasserin |4 aut | |
700 | 0 | |a KIM DOC KYU |e verfasserin |4 aut | |
700 | 0 | |a HAN SE JONG |e verfasserin |4 aut | |
700 | 0 | |a LEE HYOUNG SEOK |e verfasserin |4 aut | |
700 | 0 | |a OH HYUN CHEOL |e verfasserin |4 aut | |
700 | 0 | |a PYO SUHK NEUNG |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2018) vom: 27. Sept. |
773 | 1 | 8 | |g year:2018 |g day:27 |g month:09 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/searchResults?DB=EPODOC&locale=en_EP&query=KR20130043995A |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
912 | |a SSG-OLC-PHA | ||
936 | u | w | |j 2018 |b 27 |c 09 |
951 | |a AR | ||
952 | |j 2018 |b 27 |c 09 |