Neutralizing antibodies to the alphavbeta8 integrin complex for immunotherapy
Provided is an antibody that specifically binds human ανββ and blocks binding of TGFp peptide to ανβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the a1 helix of human β8, or the a1 helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-ανββ antibodies or antigen-binding molecules thereof..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 06. Juli Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
NISHIMURA STEPHEN L [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-07-06, Last update posted on www.tib.eu: 2024-01-15, Last updated: 2024-01-19 |
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| Patentnummer: |
AU2017335991 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA005694345 |
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| 245 | 1 | 0 | |a Neutralizing antibodies to the alphavbeta8 integrin complex for immunotherapy |
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| 520 | |a Provided is an antibody that specifically binds human ανββ and blocks binding of TGFp peptide to ανβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the a1 helix of human β8, or the a1 helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-ανββ antibodies or antigen-binding molecules thereof. | ||
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