LOW FUNCTIONAL ADCC/CDC MONOCLONAL ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF
一种低ADCC/CDC功能性单抗及其制备方法与应用。对PD-L1、PD-1、CTLA4、TNF-α、PCSK9、NGF、CD47和C5等多靶点的抗体序列进行改造,在IgG1亚型抗体重链CDR3与CH2区之间插入一段柔性氨基酸序列,可降低ADCC/CDC功能,同时不显著增加多聚体形成。上述改造抗体和原始抗体针对相同位点,但抗体亚型或糖基化不同,稳定性显著提高或/和免疫原性显著降低,半衰期延长。.
Medienart: |
Patent |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Europäisches Patentamt - (2021) vom: 26. Feb. Zur Gesamtaufnahme - year:2021 |
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Sprache: |
Unbestimmt |
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Beteiligte Personen: |
SUN LE [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
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Anmerkungen: |
Source: www.epo.org (no modifications made), Last update posted on www.epo.org: 2021-02-26, Last updated: 2021-03-11 |
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Patentnummer: |
WO2020007368 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA005006929 |
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