Compositions and methods for inhibiting HMGB1 expression
This disclosure relates to oligonucleotides, compositions and methods useful for reducing HMGB1 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of HMGB1 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of HMGB1 expression may also be designed to include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat liver fibrosis and related conditions..
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Patent| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Europäisches Patentamt - (2020) vom: 16. Jan. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ABRAMS MARC [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-01-16, Last update posted on www.tib.eu: 2024-04-29, Last updated: 2024-05-03 |
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| Patentnummer: |
AU2018294415 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA004206665 |
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| 245 | 1 | 0 | |a Compositions and methods for inhibiting HMGB1 expression |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2020-01-16, Last update posted on www.tib.eu: 2024-04-29, Last updated: 2024-05-03 | ||
| 520 | |a This disclosure relates to oligonucleotides, compositions and methods useful for reducing HMGB1 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of HMGB1 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of HMGB1 expression may also be designed to include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat liver fibrosis and related conditions. | ||
| 650 | 4 | |a bio | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a che | |
| 650 | 4 | |a C07H: Sugars; derivatives thereof; nucleosides; nucleotides; nucleic acids (derivatives of aldonic or saccharic acids c07c, c07d;aldonic acids, saccharic acids c07c0059105000, c07c0059285000;cyanohydrins c07c0255160000;glycals c07d;compounds of unknown constitution c07g;polysaccharides, derivatives thereof c08b;dna or rna concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification c12n0015000000;sugar industry c13) | |
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