APOPTOSIS INDUCERS AND THERAPEUTIC AGENTS FOR CANCER
To provide novel molecular target agents to overcome the problems of current molecular target agents which are designed to inhibit activated genes or products thereof in cancer cells but have a number of clinically serious problems such as expression of anticancer drug resistance often with insufficient therapeutic effects.SOLUTION: Disclosed herein is an apoptosis inducer that induces apoptosis in a cell in which phosphorylated ERK is constantly in a high level as compared with normal cells by further elevating the levels of phosphorylated ERK and cleaved caspase 3. Such an apoptosis inducer over-activates the ERK-MAPK signaling pathway to induce apoptosis in cells in which ERK is constantly activated, so that it can induce cell death and become a therapeutic agent to various cancers with excessively activated ERK pathway such as pancreatic cancer, colon cancer and breast cancer, wherever mutations occur in the ERK signaling pathway.SELECTED DRAWING: Figure 2.
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Patent| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Europäisches Patentamt - (2019) vom: 06. Juni Zur Gesamtaufnahme - year:2019 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
SUGIURA REIKO [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2019-06-06, Last update posted on www.tib.eu: 2024-05-07, Last updated: 2024-05-10 |
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| Patentnummer: |
JP2019085381 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA004081870 |
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| 520 | |a To provide novel molecular target agents to overcome the problems of current molecular target agents which are designed to inhibit activated genes or products thereof in cancer cells but have a number of clinically serious problems such as expression of anticancer drug resistance often with insufficient therapeutic effects.SOLUTION: Disclosed herein is an apoptosis inducer that induces apoptosis in a cell in which phosphorylated ERK is constantly in a high level as compared with normal cells by further elevating the levels of phosphorylated ERK and cleaved caspase 3. Such an apoptosis inducer over-activates the ERK-MAPK signaling pathway to induce apoptosis in cells in which ERK is constantly activated, so that it can induce cell death and become a therapeutic agent to various cancers with excessively activated ERK pathway such as pancreatic cancer, colon cancer and breast cancer, wherever mutations occur in the ERK signaling pathway.SELECTED DRAWING: Figure 2 | ||
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