HLA CLASS I BINDING T-CELL RECEPTOR TO MUTANT RAS
To provide a further therapy to cancer.SOLUTION: Provided is an isolated or purified T-cell receptor (TCR) that has antigen specificity to a mutant RAS amino acid sequence presented by a human leukocyte antigen (HLA) class I molecule. Also provided are associated polypeptide and protein, and associated nucleic acid, a recombinant expression vector, a host cell, a cell cluster, and a pharmaceutical composition. Also provided are a method for detecting the presence of cancer in a mammal, and a method for treating or preventing cancer in a mammal.SELECTED DRAWING: Figure 1A.
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
RAMI YOSEPH [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-12, Last update posted on www.tib.eu: 2024-04-16, Last updated: 2024-04-19 |
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| Patentnummer: |
JP2023175703 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002963663 |
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| 520 | |a To provide a further therapy to cancer.SOLUTION: Provided is an isolated or purified T-cell receptor (TCR) that has antigen specificity to a mutant RAS amino acid sequence presented by a human leukocyte antigen (HLA) class I molecule. Also provided are associated polypeptide and protein, and associated nucleic acid, a recombinant expression vector, a host cell, a cell cluster, and a pharmaceutical composition. Also provided are a method for detecting the presence of cancer in a mammal, and a method for treating or preventing cancer in a mammal.SELECTED DRAWING: Figure 1A | ||
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