RVG15 peptide modified brain-targeting metal organic framework drug carrier as well as preparation method and application thereof
The invention belongs to the technical field of medicines, and discloses a preparation method and application of a rabies virus glycoprotein-derived peptide 15 (RVG-15) modified brain-targeting metal organic framework drug carrier. According to the invention, brain targeting peptide RVG is used as a targeting group and is covalently bound with PEG to obtain the RVG-PEG-COOH targeting conjugate. And modifying the RVG-PEG-COOH on the surface of a metal organic framework material ZIF-8 through the interaction of positive and negative charges, so as to prepare the brain-targeting metal organic framework drug carrier. The brain-targeting metal organic framework drug carrier prepared by the invention can entrap chemotherapeutic drugs through a simple one-step entrapment method, and has the advantages of high drug loading rate, good stability, strong brain-targeting effect and the like..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 26. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
KO JONG-HO [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-26, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117442749 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002785250 |
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| 520 | |a The invention belongs to the technical field of medicines, and discloses a preparation method and application of a rabies virus glycoprotein-derived peptide 15 (RVG-15) modified brain-targeting metal organic framework drug carrier. According to the invention, brain targeting peptide RVG is used as a targeting group and is covalently bound with PEG to obtain the RVG-PEG-COOH targeting conjugate. And modifying the RVG-PEG-COOH on the surface of a metal organic framework material ZIF-8 through the interaction of positive and negative charges, so as to prepare the brain-targeting metal organic framework drug carrier. The brain-targeting metal organic framework drug carrier prepared by the invention can entrap chemotherapeutic drugs through a simple one-step entrapment method, and has the advantages of high drug loading rate, good stability, strong brain-targeting effect and the like. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
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