ShRNA (short hairpin ribonucleic acid) for interfering NLRP3 protein expression in microglial cells and application of shRNA
The invention discloses shRNA (short hairpin Ribonucleic Acid) capable of interfering NLRP3 protein expression in microglial cells and application of the shRNA. The shRNA is shNLRP3-1725, shNLRP3-2052 or shNLRP3-2411, and the shRNA can be used for interfering NLRP3 protein expression in microglial cells. The positive-sense strand and the antisense strand of the shNLRP3-1725 are respectively as shown in SEQ ID NO.1-2, the positive-sense strand and the antisense strand of the shNLRP3-2052 are respectively as shown in SEQ ID NO.3-4, and the positive-sense strand and the antisense strand of the shNLRP3-2411 are respectively as shown in SEQ ID NO.5-6; wherein the TCTAAGAGA is a loop sequence, and the TCTAAGAGA is a The shRNA for interfering the expression of the NLRP3 protein in the microglia, disclosed by the invention, can be used for effectively relieving the pathological process related to PD (Protein Disease)..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 26. Jan. Zur Gesamtaufnahme - year:2024 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
GAO YA [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-26, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
|---|
| Patentnummer: |
CN117448329 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA002724731 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA002724731 | ||
| 003 | DE-627 | ||
| 005 | 20240329160233.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240329s2024 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA002724731 | ||
| 035 | |a (EPA)CN117448329 | ||
| 035 | |a (EPA)89594139 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a GAO YA |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a ShRNA (short hairpin ribonucleic acid) for interfering NLRP3 protein expression in microglial cells and application of shRNA |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2024-01-26, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 | ||
| 520 | |a The invention discloses shRNA (short hairpin Ribonucleic Acid) capable of interfering NLRP3 protein expression in microglial cells and application of the shRNA. The shRNA is shNLRP3-1725, shNLRP3-2052 or shNLRP3-2411, and the shRNA can be used for interfering NLRP3 protein expression in microglial cells. The positive-sense strand and the antisense strand of the shNLRP3-1725 are respectively as shown in SEQ ID NO.1-2, the positive-sense strand and the antisense strand of the shNLRP3-2052 are respectively as shown in SEQ ID NO.3-4, and the positive-sense strand and the antisense strand of the shNLRP3-2411 are respectively as shown in SEQ ID NO.5-6; wherein the TCTAAGAGA is a loop sequence, and the TCTAAGAGA is a The shRNA for interfering the expression of the NLRP3 protein in the microglia, disclosed by the invention, can be used for effectively relieving the pathological process related to PD (Protein Disease). | ||
| 650 | 4 | |a bio | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a WANG CHENHONG |4 aut | |
| 700 | 0 | |a ZHOU XU |4 aut | |
| 700 | 0 | |a NIU HAICHEN |4 aut | |
| 700 | 0 | |a LI HAIYING |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2024) vom: 26. Jan. |
| 773 | 1 | 8 | |g year:2024 |g day:26 |g month:01 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/89594139/publication/CN117448329A1?q=CN117448329 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 26 |c 01 | ||