Amide compound as well as preparation method, pharmaceutical composition and application thereof
The invention provides a compound containing a general formula I as well as a preparation method, a pharmaceutical composition and application thereof, and particularly provides a compound with a structure as shown in the general formula I as well as a raceme, an R-isomer, an S-isomer, a pharmaceutically acceptable salt or a mixture of the raceme, the R-isomer, the S-isomer and the pharmaceutically acceptable salt. The compound has good inhibitory activity on PL protease, so that the compound can be used for treating, preventing and relieving diseases related to the PL protease, and particularly can be used for treating viral diseases with the PL protease, such as diseases caused by SARS-CoV-2, SARS-CoV, MERS-CoV and the like. # imgabs0 #.
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 16. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHOU YU [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-16, Last update posted on www.tib.eu: 2024-04-30, Last updated: 2024-05-03 |
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| Patentnummer: |
CN117402156 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002697246 |
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| 520 | |a The invention provides a compound containing a general formula I as well as a preparation method, a pharmaceutical composition and application thereof, and particularly provides a compound with a structure as shown in the general formula I as well as a raceme, an R-isomer, an S-isomer, a pharmaceutically acceptable salt or a mixture of the raceme, the R-isomer, the S-isomer and the pharmaceutically acceptable salt. The compound has good inhibitory activity on PL protease, so that the compound can be used for treating, preventing and relieving diseases related to the PL protease, and particularly can be used for treating viral diseases with the PL protease, such as diseases caused by SARS-CoV-2, SARS-CoV, MERS-CoV and the like. # imgabs0 # | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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