Application of m6A methyltransferase IGF2BP2 in preparation of neoadjuvant radiotherapy resistance marker for diagnosing breast cancer
The invention belongs to the technical field of m6a methyltransferase science, and particularly relates to application of m6A methyltransferase IGF2BP2 in preparation of a neoadjuvant radiotherapy resistance marker for diagnosing breast cancer, breast cancer diagnosis refers to detection of the expression level of IGF2BP2 gene in a breast cancer tissue sample by adopting an RT-qPCR (real-time quantitative polymerase chain reaction) technology. The expression of the IGF2BP2 gene in a breast cancer tissue sample is up-regulated. The effect of the IGF2BP2 in breast cancer neoadjuvant radiotherapy resistance is confirmed for the first time, the expression quantity of the IGF2BP2 in breast cancer radiotherapy resistance tissues is up-regulated, and the breast cancer cell radiotherapy resistance is promoted. The m6A methyltransferase IGF2BP2 can be used for predicting breast cancer radiotherapy resistance and helping a patient to adjust a treatment strategy in time, and can be used as a potential target spot for clinical breast cancer diagnosis and treatment..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 16. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHANG MING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-16, Last update posted on www.tib.eu: 2024-04-22, Last updated: 2024-04-26 |
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| Patentnummer: |
CN117402972 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002583259 |
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| 520 | |a The invention belongs to the technical field of m6a methyltransferase science, and particularly relates to application of m6A methyltransferase IGF2BP2 in preparation of a neoadjuvant radiotherapy resistance marker for diagnosing breast cancer, breast cancer diagnosis refers to detection of the expression level of IGF2BP2 gene in a breast cancer tissue sample by adopting an RT-qPCR (real-time quantitative polymerase chain reaction) technology. The expression of the IGF2BP2 gene in a breast cancer tissue sample is up-regulated. The effect of the IGF2BP2 in breast cancer neoadjuvant radiotherapy resistance is confirmed for the first time, the expression quantity of the IGF2BP2 in breast cancer radiotherapy resistance tissues is up-regulated, and the breast cancer cell radiotherapy resistance is promoted. The m6A methyltransferase IGF2BP2 can be used for predicting breast cancer radiotherapy resistance and helping a patient to adjust a treatment strategy in time, and can be used as a potential target spot for clinical breast cancer diagnosis and treatment. | ||
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