Antibodies and their use in inhibition of cancer stem cells
The present invention relates to antibodies and their use in inhibition of cancer stem cells. According to the present invention, the survivin recombinant protein is adopted as the immunogen to immunize the mouse, and the hybridoma technology is adopted to prepare the survivin monoclonal antibody, wherein the survivin monoclonal antibody has good survivin binding ability and specificity; after the antibody acts on nasopharyngeal carcinoma cells, proliferation of the nasopharyngeal carcinoma cells and expression of survivin protein in the cells can be inhibited. The monoclonal antibody provided by the invention has a wide prospect in cancer treatment..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 25. Apr. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LU DEQING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-04-25, Last update posted on www.tib.eu: 2023-09-26, Last updated: 2023-09-29 |
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| Patentnummer: |
CN115998860 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002507447 |
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| 520 | |a The present invention relates to antibodies and their use in inhibition of cancer stem cells. According to the present invention, the survivin recombinant protein is adopted as the immunogen to immunize the mouse, and the hybridoma technology is adopted to prepare the survivin monoclonal antibody, wherein the survivin monoclonal antibody has good survivin binding ability and specificity; after the antibody acts on nasopharyngeal carcinoma cells, proliferation of the nasopharyngeal carcinoma cells and expression of survivin protein in the cells can be inhibited. The monoclonal antibody provided by the invention has a wide prospect in cancer treatment. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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