COMPOUND HAVING PYRIDOIMIDAZOLE AS PARENT NUCLEUS, AND PREPARATION METHOD FOR AND USE OF COMPOUND
Disclosed in the present invention are a compound having pyridoimidazole as the parent nucleus, and a preparation method for and a use of the compound. The compound having pyridoimidazole as the parent nucleus provided by the present invention is novel in structure and simple in preparation method, can specifically inhibit activation of NLRP3 inflammasome to reduce secretion of mature interleukin IL-1β, thereby relieving inflammatory injury, alleviating the inflammatory microenvironment, and achieving remarkable anti-inflammatory activity, and has no obvious toxicity to THP-1 cells. The compound in the present invention can be prepared into an anti-inflammatory drug and used for treatment of inflammation-associated diseases, such as rheumatic arthritis, rheumatoid arthritis, inflammatory intestinal diseases, gout, atherosclerosis, non-alcoholic fatty liver disease, cryopyrin-associated periodic syndrome, chronic kidney disease, diabetes, and neurodegenerative diseases..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 27. Juli Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
XU LILI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-07-27, Last update posted on www.tib.eu: 2023-09-21, Last updated: 2023-09-29 |
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| Patentnummer: |
WO2023137885 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002411911 |
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| 520 | |a Disclosed in the present invention are a compound having pyridoimidazole as the parent nucleus, and a preparation method for and a use of the compound. The compound having pyridoimidazole as the parent nucleus provided by the present invention is novel in structure and simple in preparation method, can specifically inhibit activation of NLRP3 inflammasome to reduce secretion of mature interleukin IL-1β, thereby relieving inflammatory injury, alleviating the inflammatory microenvironment, and achieving remarkable anti-inflammatory activity, and has no obvious toxicity to THP-1 cells. The compound in the present invention can be prepared into an anti-inflammatory drug and used for treatment of inflammation-associated diseases, such as rheumatic arthritis, rheumatoid arthritis, inflammatory intestinal diseases, gout, atherosclerosis, non-alcoholic fatty liver disease, cryopyrin-associated periodic syndrome, chronic kidney disease, diabetes, and neurodegenerative diseases. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
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