암을 치료하는 방법
본 발명은 폴리(ADP-리보스) 폴리머라제 (PARP) 억제제, 예컨대 니라파립을 사용하여 상동 재조합 복구 (HRR) 경로에 수반되는 적어도 1종의 비-BRCA1/2 유전자에 결함을 갖는 암 환자를 치료하는 방법을 제공한다. 특히, BRCA1, BRCA2, ATM, ATR, BAP1, BARD1, BLM, BRIP1, MRE11A, NBN, PALB2, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, XRCC2, TP53 또는 RB1로 이루어진 군으로부터 선택된 적어도 1종의 유전자에 결함을 갖는 암 환자가 니라파립을 사용한 치료로부터 이익을 얻을 수 있다..
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Patent| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Europäisches Patentamt - (2020) vom: 09. Sept. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Koreanisch |
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| Beteiligte Personen: |
FENG BIN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-09-09, Last update posted on www.tib.eu: 2023-09-20, Last updated: 2023-09-29 |
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| Patentnummer: |
KR20200105862 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002193639 |
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| 520 | |a 본 발명은 폴리(ADP-리보스) 폴리머라제 (PARP) 억제제, 예컨대 니라파립을 사용하여 상동 재조합 복구 (HRR) 경로에 수반되는 적어도 1종의 비-BRCA1/2 유전자에 결함을 갖는 암 환자를 치료하는 방법을 제공한다. 특히, BRCA1, BRCA2, ATM, ATR, BAP1, BARD1, BLM, BRIP1, MRE11A, NBN, PALB2, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, XRCC2, TP53 또는 RB1로 이루어진 군으로부터 선택된 적어도 1종의 유전자에 결함을 갖는 암 환자가 니라파립을 사용한 치료로부터 이익을 얻을 수 있다. | ||
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