Luminescent acid-sensitive polymer, preparation method and application
The invention relates to the technical field of biomedical polymer materials, and discloses a luminous acid-sensitive polymer as well as a preparation method and application thereof. The preparation method comprises the following steps: step 1, dissolving the block copolymer in an organic solvent; step 2, adjusting alkali, and adding the graft to carry out nucleophilic addition reaction; and step 3, after full reaction, carrying out suction filtration or precipitation, and drying to obtain the required product. Wherein the block copolymer comprises a hydrophobic segment and a hydrophilic segment, and the hydrophobic segment has an active amino group; the molecular structure of the graft contains an aldehyde group and a conjugated structure; the molar ratio of the active amino to the graft in the step 2 is (0.5-1): (1-5). The polymer has a relatively stable structure, is sensitive to weak acidic pH conditions, has a dual-luminescence mode, and can realize efficient and accurate drug release and diagnosis and treatment integration in multiple scenes..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 12. Mai Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
DING MINGMING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-05-12, Last update posted on www.tib.eu: 2023-09-26, Last updated: 2023-09-29 |
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| Patentnummer: |
CN116102736 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002187159 |
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| 520 | |a The invention relates to the technical field of biomedical polymer materials, and discloses a luminous acid-sensitive polymer as well as a preparation method and application thereof. The preparation method comprises the following steps: step 1, dissolving the block copolymer in an organic solvent; step 2, adjusting alkali, and adding the graft to carry out nucleophilic addition reaction; and step 3, after full reaction, carrying out suction filtration or precipitation, and drying to obtain the required product. Wherein the block copolymer comprises a hydrophobic segment and a hydrophilic segment, and the hydrophobic segment has an active amino group; the molecular structure of the graft contains an aldehyde group and a conjugated structure; the molar ratio of the active amino to the graft in the step 2 is (0.5-1): (1-5). The polymer has a relatively stable structure, is sensitive to weak acidic pH conditions, has a dual-luminescence mode, and can realize efficient and accurate drug release and diagnosis and treatment integration in multiple scenes. | ||
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