Oral solid controlled-release preparation based on microdroplet spraying and preparation method of oral solid controlled-release preparation
The invention belongs to the field of drug design, and discloses a preparation method of an oral solid controlled-release preparation based on microdroplet jetting, which comprises the following steps: S1, separating and designing the distribution of active pharmaceutical ingredients and pharmaceutic adjuvants in the preparation; s2, recombining the separated and designed component information; s3, converting the combined component distribution information into slices which can be identified by 3D printing equipment; s4, a two-channel micro-droplet jetting 3D printer is used for printing; s5, the powder material is used for receiving the components sprayed by the printer, so that the solid preparation is formed through bonding. According to the method for defining the concentration distribution of the active pharmaceutical ingredients in the preparation through the concentration gradient function, the problem that the controlled release preparation cannot achieve the ideal controlled release effect is solved in principle; the oral solid controlled-release preparation is prepared by 3D printing according to the dual-channel droplet jetting principle, so that the existing preparation process mode can be changed, and the oral solid controlled-release preparation meeting the function design requirement can be prepared..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 14. Apr. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG LI [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-04-14, Last update posted on www.tib.eu: 2023-09-26, Last updated: 2023-09-29 |
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| Patentnummer: |
CN115966265 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA002093707 |
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| 245 | 1 | 0 | |a Oral solid controlled-release preparation based on microdroplet spraying and preparation method of oral solid controlled-release preparation |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-04-14, Last update posted on www.tib.eu: 2023-09-26, Last updated: 2023-09-29 | ||
| 520 | |a The invention belongs to the field of drug design, and discloses a preparation method of an oral solid controlled-release preparation based on microdroplet jetting, which comprises the following steps: S1, separating and designing the distribution of active pharmaceutical ingredients and pharmaceutic adjuvants in the preparation; s2, recombining the separated and designed component information; s3, converting the combined component distribution information into slices which can be identified by 3D printing equipment; s4, a two-channel micro-droplet jetting 3D printer is used for printing; s5, the powder material is used for receiving the components sprayed by the printer, so that the solid preparation is formed through bonding. According to the method for defining the concentration distribution of the active pharmaceutical ingredients in the preparation through the concentration gradient function, the problem that the controlled release preparation cannot achieve the ideal controlled release effect is solved in principle; the oral solid controlled-release preparation is prepared by 3D printing according to the dual-channel droplet jetting principle, so that the existing preparation process mode can be changed, and the oral solid controlled-release preparation meeting the function design requirement can be prepared. | ||
| 650 | 4 | |a G16C: Computational chemistry; chemoinformatics; computational materials science | |
| 650 | 4 | |a che | |
| 650 | 4 | |a inf | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a G06T: Image data processing or generation, in general | |
| 650 | 4 | |a B33Y: Additive manufacturing, i.e. manufacturing of three-dimensional [3d] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3d printing, stereolithography or selective laser sintering | |
| 650 | 4 | |a B29C: Shaping or joining of plastics; shaping of material in a plastic state, not otherwise provided for; after-treatment of the shaped products, e.g. repairing (making preforms b29b0011000000; making laminated products by combining previously unconnected layers which become one product whose layers will remain together b32b0037000000-b32b0041000000) | |
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