结合冠状病毒SARS-CoV-2和SARS-CoV核衣壳蛋白的特异性抗体及其应用
本发明公开了一种结合冠状病毒SARS‑CoV‑2和SARS‑CoV核衣壳蛋白(Nucleocapsid protein)的特异性抗体及其应用。本发明中抗体的CDRs的序列如SEQ ID NO.1至SEQ ID NO.6所示。本发明提供的抗体，其包含特定的序列的CDRs，能够特异性地与SARS‑CoV‑2和SARS‑CoV核衣壳蛋白结合，同时与另一种高致病性冠状病毒MERS‑CoV的核衣壳蛋白有微弱结合反应。本发明提供的抗体，靶向性强，结合活性高，本发明提供的制备方法制备抗体，纯度高，可大量制备。整体上，本发明的抗体可以用于SARS‑CoV和SARS‑CoV‑2感染检测方法的开发与优化。.
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 12. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Chinesisch |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-03-12, Last update posted on www.tib.eu: 2024-03-27, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117143227 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA001539159 |
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| 520 | |a 本发明公开了一种结合冠状病毒SARS‑CoV‑2和SARS‑CoV核衣壳蛋白(Nucleocapsid protein)的特异性抗体及其应用。本发明中抗体的CDRs的序列如SEQ ID NO.1至SEQ ID NO.6所示。本发明提供的抗体，其包含特定的序列的CDRs，能够特异性地与SARS‑CoV‑2和SARS‑CoV核衣壳蛋白结合，同时与另一种高致病性冠状病毒MERS‑CoV的核衣壳蛋白有微弱结合反应。本发明提供的抗体，靶向性强，结合活性高，本发明提供的制备方法制备抗体，纯度高，可大量制备。整体上，本发明的抗体可以用于SARS‑CoV和SARS‑CoV‑2感染检测方法的开发与优化。 | ||
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