一种抗菌多肽及应用
本发明公开了一种抗菌多肽及应用。其来源于新型冠状病毒(SARS‑CoV‑2)的Replicase polyprotein 1a蛋白，其氨基酸序列如SEQ ID No.01或SEQ ID No.03所示。本发明的抗菌多肽对金葡菌等革兰阳性菌和大肠杆菌、肺炎克雷伯菌、鲍曼不动杆菌等常见的临床致病菌具有较强的抗菌活性，对多种多药耐药菌具有较强的抗菌活性，如耐甲氧西林的金葡菌、耐碳青霉烯的大肠杆菌、耐碳青霉烯的肺炎克雷伯菌均对其敏感，特别是耐碳青霉烯的鲍曼不动杆菌对Cov6多肽的MIC低至4μM；本发明抗菌多肽还具有溶血及细胞毒性极低的优点，具备作为药物和食品添加剂开发的条件，具有广泛的应用前景。.
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 12. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Chinesisch |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-03-12, Last update posted on www.tib.eu: 2024-03-27, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117004590 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA001517902 |
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| 520 | |a 本发明公开了一种抗菌多肽及应用。其来源于新型冠状病毒(SARS‑CoV‑2)的Replicase polyprotein 1a蛋白，其氨基酸序列如SEQ ID No.01或SEQ ID No.03所示。本发明的抗菌多肽对金葡菌等革兰阳性菌和大肠杆菌、肺炎克雷伯菌、鲍曼不动杆菌等常见的临床致病菌具有较强的抗菌活性，对多种多药耐药菌具有较强的抗菌活性，如耐甲氧西林的金葡菌、耐碳青霉烯的大肠杆菌、耐碳青霉烯的肺炎克雷伯菌均对其敏感，特别是耐碳青霉烯的鲍曼不动杆菌对Cov6多肽的MIC低至4μM；本发明抗菌多肽还具有溶血及细胞毒性极低的优点，具备作为药物和食品添加剂开发的条件，具有广泛的应用前景。 | ||
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