Mesenchymal stem cell exosome reagent for inducing transformation of pro-inflammatory astrocytes to anti-inflammatory phenotype, induction method and application
The invention discloses a mesenchymal stem cell exosome reagent for inducing proinflammatory astrocytes to transform into anti-inflammatory phenotypes, an induction method and application, and belongs to the technical field of biological medicines. The invention provides a mesenchymal stem cell exosome reagent for inducing transformation from pro-inflammatory A1 type astrocytes to anti-inflammatory A2 phenotype, and the mesenchymal stem cell exosome reagent is used for co-incubating a mesenchymal stem cell exosome over-expressing miR-124 or miR-124 mimic with the astrocytes, so that the polarization phenotype and cytological characteristics of the astrocytes are changed; related proinflammatory response caused by astrocyte A1 is relieved, astrocyte is induced to be polarized to A2, an anti-inflammatory effect is achieved, and regeneration and repair of inflammatory injury are promoted. The preparation process is simple, expression is stable, the preparation system is easy to control quality, and industrialization is easy..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 09. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
JI KWANG-BUM [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-09, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117357561 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA001427105 |
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| 520 | |a The invention discloses a mesenchymal stem cell exosome reagent for inducing proinflammatory astrocytes to transform into anti-inflammatory phenotypes, an induction method and application, and belongs to the technical field of biological medicines. The invention provides a mesenchymal stem cell exosome reagent for inducing transformation from pro-inflammatory A1 type astrocytes to anti-inflammatory A2 phenotype, and the mesenchymal stem cell exosome reagent is used for co-incubating a mesenchymal stem cell exosome over-expressing miR-124 or miR-124 mimic with the astrocytes, so that the polarization phenotype and cytological characteristics of the astrocytes are changed; related proinflammatory response caused by astrocyte A1 is relieved, astrocyte is induced to be polarized to A2, an anti-inflammatory effect is achieved, and regeneration and repair of inflammatory injury are promoted. The preparation process is simple, expression is stable, the preparation system is easy to control quality, and industrialization is easy. | ||
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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