Nanoprobe for targeting prostatic cancer as well as preparation method and application of nanoprobe
The invention discloses a prostatic cancer targeting nanoprobe as well as a preparation method and application thereof. The expression of the nanoprobe is AuNC (at) MOF/OLA-PSMA-617, Olaparib is located in a gold nanocage, MOF is coated outside the gold nanocage, and PSMA-617 and MOF are combined to form surface modification. The mass ratio of the MOFs to the gold nanocage is (30-35): 60, and the mass ratio of the olaparib to the gold nanocage is (5-10): 60. According to the invention, a gold nanomaterial is combined with olaparib and a metal organic framework material, and the metal organic framework material is subjected to targeted surface modification, so that the radiotherapy sensitization nanoprobe with clinical transformation application potential is constructed, and hope is brought to treatment or diagnosis of prostatic cancer..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 09. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
TAN HAISONG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-09, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117357663 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA00140007X |
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| 520 | |a The invention discloses a prostatic cancer targeting nanoprobe as well as a preparation method and application thereof. The expression of the nanoprobe is AuNC (at) MOF/OLA-PSMA-617, Olaparib is located in a gold nanocage, MOF is coated outside the gold nanocage, and PSMA-617 and MOF are combined to form surface modification. The mass ratio of the MOFs to the gold nanocage is (30-35): 60, and the mass ratio of the olaparib to the gold nanocage is (5-10): 60. According to the invention, a gold nanomaterial is combined with olaparib and a metal organic framework material, and the metal organic framework material is subjected to targeted surface modification, so that the radiotherapy sensitization nanoprobe with clinical transformation application potential is constructed, and hope is brought to treatment or diagnosis of prostatic cancer. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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