PH response dye platform as well as preparation method and application thereof
The invention discloses a pH response dye platform as well as a preparation method and application thereof. According to the pH response dye platform and the preparation method thereof, accurate regulation and control of pH are realized by introducing heteroarylamine at the ninth site of a traditional rhodamine dye and replacing different heteroatoms at the tenth site of the traditional rhodamine dye; and a pH response dye platform (composed of a series of pH response dyes suitable for different pH ranges) across the full physiological pH range is constructed based on the strategy. Meanwhile, the pH response dye in the platform has good photophysical properties and sensitive pH response capability, and covers the response range of the pH value from 0.5 to 7.0, so that the monitoring requirements of different pH microenvironments in a living body can be met..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 09. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
LI KUN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-09, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117362331 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA001398962 |
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| 245 | 1 | 0 | |a PH response dye platform as well as preparation method and application thereof |
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| 520 | |a The invention discloses a pH response dye platform as well as a preparation method and application thereof. According to the pH response dye platform and the preparation method thereof, accurate regulation and control of pH are realized by introducing heteroarylamine at the ninth site of a traditional rhodamine dye and replacing different heteroatoms at the tenth site of the traditional rhodamine dye; and a pH response dye platform (composed of a series of pH response dyes suitable for different pH ranges) across the full physiological pH range is constructed based on the strategy. Meanwhile, the pH response dye in the platform has good photophysical properties and sensitive pH response capability, and covers the response range of the pH value from 0.5 to 7.0, so that the monitoring requirements of different pH microenvironments in a living body can be met. | ||
| 650 | 4 | |a C07F: Acyclic, carbocyclic, or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium (metal-containing porphyrins c07d0487220000;macromolecular compounds c08) | |
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a C09K: Materials for applications not otherwise provided for; applications of materials not otherwise provided for | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a C09B: Organic dyes or closely-related compounds for producing dyes; mordants; lakes (fermentation or enzyme-using processes to synthesise a desired chemical compound c12p) | |
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