1-substituted cinnamoyl-2-oxolycorine compound as well as preparation method and application thereof
The invention provides a 1-substituted cinnamoyl-2-oxolycorine compound as well as a preparation method and application thereof, the structure of the compound is shown as a formula I: # imgabs0 #, one or more R groups are arranged on a benzene ring and are substituent groups on the benzene ring, and one or more R groups are substituent groups on the benzene ring. Wherein R groups are selected from hydrogen, C1-6 alkyl groups, C1-6 alkyl alkoxy groups, halogen, halogenated C1-6 alkyl groups, halogenated C1-6 alkoxy groups, nitryl groups and dioxo groups. The compound shows an excellent antiviral effect, especially for type I herpes simplex virus (HSV-1), and the compound has better safety..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 05. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
YAN SHIQIANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-05, Last update posted on www.tib.eu: 2024-03-18, Last updated: 2024-03-22 |
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| Patentnummer: |
CN117343072 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA001138685 |
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| 245 | 1 | 0 | |a 1-substituted cinnamoyl-2-oxolycorine compound as well as preparation method and application thereof |
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| 520 | |a The invention provides a 1-substituted cinnamoyl-2-oxolycorine compound as well as a preparation method and application thereof, the structure of the compound is shown as a formula I: # imgabs0 #, one or more R groups are arranged on a benzene ring and are substituent groups on the benzene ring, and one or more R groups are substituent groups on the benzene ring. Wherein R groups are selected from hydrogen, C1-6 alkyl groups, C1-6 alkyl alkoxy groups, halogen, halogenated C1-6 alkyl groups, halogenated C1-6 alkoxy groups, nitryl groups and dioxo groups. The compound shows an excellent antiviral effect, especially for type I herpes simplex virus (HSV-1), and the compound has better safety. | ||
| 650 | 4 | |a C07D: Heterocyclic compounds (macromolecular compounds c08) | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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