Preparation method of cell membrane bionic preparation capable of being preserved in freeze-drying mode and product and application of cell membrane bionic preparation
The invention discloses a preparation method of a cell membrane bionic preparation capable of being preserved in a freeze-drying manner. The preparation method comprises the following steps: (1) extracting a cell membrane; (2) preparing a liposome or a drug-loaded liposome; (3) resuspending cell membranes, liposomes or drug-loaded liposomes by using a buffer solution containing a freeze-drying protective agent; (4) mixing the resuspended cell membrane with a liposome or a drug-loaded liposome to prepare a cell membrane bionic preparation; and (5) pre-freezing the cell membrane bionic preparation, and then carrying out freeze-drying operation to prepare the freeze-dried preparation. The invention further provides the cell membrane bionic preparation capable of being stored in a freeze-drying mode and obtained through the preparation method and application of the cell membrane bionic preparation serving as a drug targeted delivery carrier. The cell membrane freeze-dried bionic preparation prepared by the invention is stable in appearance and good in resolubility, can effectively retain the function of cell membrane protein, and solves the technical problem that the existing cell membrane bionic preparation cannot be stably stored for a long time after being prepared..
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 05. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
ZHOU YANJUN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-05, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 |
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| Patentnummer: |
CN117338731 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA00113017X |
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| 245 | 1 | 0 | |a Preparation method of cell membrane bionic preparation capable of being preserved in freeze-drying mode and product and application of cell membrane bionic preparation |
| 264 | 1 | |c 2024 | |
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| 500 | |a Source: www.epo.org (no modifications made), First posted: 2024-01-05, Last update posted on www.tib.eu: 2024-03-25, Last updated: 2024-03-29 | ||
| 520 | |a The invention discloses a preparation method of a cell membrane bionic preparation capable of being preserved in a freeze-drying manner. The preparation method comprises the following steps: (1) extracting a cell membrane; (2) preparing a liposome or a drug-loaded liposome; (3) resuspending cell membranes, liposomes or drug-loaded liposomes by using a buffer solution containing a freeze-drying protective agent; (4) mixing the resuspended cell membrane with a liposome or a drug-loaded liposome to prepare a cell membrane bionic preparation; and (5) pre-freezing the cell membrane bionic preparation, and then carrying out freeze-drying operation to prepare the freeze-dried preparation. The invention further provides the cell membrane bionic preparation capable of being stored in a freeze-drying mode and obtained through the preparation method and application of the cell membrane bionic preparation serving as a drug targeted delivery carrier. The cell membrane freeze-dried bionic preparation prepared by the invention is stable in appearance and good in resolubility, can effectively retain the function of cell membrane protein, and solves the technical problem that the existing cell membrane bionic preparation cannot be stably stored for a long time after being prepared. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
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