CELLULAR AND TISSUE CLEARANCE OF MISFOLDED PROTEINS AND USES THEREOF
Describe herein are methods and products for increasing the secretion of extracellular vesicles (EVs) from a cell via ganglioside treatment. Such increased secretion may be used for example for increasing the removal of misfolded proteins from a cell, and in turn for the prevention or treatment of a misfolded protein disease. Ganglioside-enriched EVs may be produced, and which further results in an increased microglial uptake of the ganglioside-enriched EVs..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Juni Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
SIPIONE SIMONETTA [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-06-15, Last update posted on www.tib.eu: 2023-09-28, Last updated: 2023-09-29 |
|---|
| Patentnummer: |
WO2023102665 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA000787094 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA000787094 | ||
| 003 | DE-627 | ||
| 005 | 20240327214213.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240315s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA000787094 | ||
| 035 | |a (EPA)WO2023102665 | ||
| 035 | |a (EPA)86729299 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a SIPIONE SIMONETTA |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CELLULAR AND TISSUE CLEARANCE OF MISFOLDED PROTEINS AND USES THEREOF |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-06-15, Last update posted on www.tib.eu: 2023-09-28, Last updated: 2023-09-29 | ||
| 520 | |a Describe herein are methods and products for increasing the secretion of extracellular vesicles (EVs) from a cell via ganglioside treatment. Such increased secretion may be used for example for increasing the removal of misfolded proteins from a cell, and in turn for the prevention or treatment of a misfolded protein disease. Ganglioside-enriched EVs may be produced, and which further results in an increased microglial uptake of the ganglioside-enriched EVs. | ||
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a C07H: Sugars; derivatives thereof; nucleosides; nucleotides; nucleic acids (derivatives of aldonic or saccharic acids c07c, c07d;aldonic acids, saccharic acids c07c0059105000, c07c0059285000;cyanohydrins c07c0255160000;glycals c07d;compounds of unknown constitution c07g;polysaccharides, derivatives thereof c08b;dna or rna concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification c12n0015000000;sugar industry c13) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a bio | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a VAIBHAVI KADAM |4 aut | |
| 700 | 0 | |a MONYROR JOHN |4 aut | |
| 700 | 0 | |a MORALES BURBANO LUIS CARLOS |4 aut | |
| 700 | 0 | |a POSSE DE CHAVES ELENA |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 15. Juni |
| 773 | 1 | 8 | |g year:2023 |g day:15 |g month:06 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/86729299/publication/WO2023102665A1?q=WO2023102665 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 15 |c 06 | ||