Application of combination of isoxazole-9 and mesenchymal stem cells in preparation of medicine for preventing or treating acute lung injury
The invention provides application of isoxazole-9 combined mesenchymal stem cells in preparation of a medicine for preventing or treating acute lung injury. The application is used for preventing or treating the acute lung injury. The invention further provides application of the composition containing the isoxazole-9 and the mesenchymal stem cells in preparation of drugs for preventing or treating acute lung injury. The invention finds that ISX-9 can improve the ALI treatment capability of MSCs for the first time, and proves that ISX-9 can improve the duration and strength of the action of the mesenchymal stem cells in the lung and enhance the ALI treatment capability of the mesenchymal stem cells. The scheme has been verified in cell and mouse ALI models, and has potential clinical application value..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 19. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
FENG YUN [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-19, Last update posted on www.tib.eu: 2024-03-13, Last updated: 2024-03-22 |
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| Patentnummer: |
CN117243977 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000777498 |
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| 520 | |a The invention provides application of isoxazole-9 combined mesenchymal stem cells in preparation of a medicine for preventing or treating acute lung injury. The application is used for preventing or treating the acute lung injury. The invention further provides application of the composition containing the isoxazole-9 and the mesenchymal stem cells in preparation of drugs for preventing or treating acute lung injury. The invention finds that ISX-9 can improve the ALI treatment capability of MSCs for the first time, and proves that ISX-9 can improve the duration and strength of the action of the mesenchymal stem cells in the lung and enhance the ALI treatment capability of the mesenchymal stem cells. The scheme has been verified in cell and mouse ALI models, and has potential clinical application value. | ||
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