Crosslinked cyclodextrin metal organic framework capable of loading ibuprofen and preparation method thereof
The invention provides a cross-linked cyclodextrin metal organic framework capable of loading ibuprofen and a preparation method of the cross-linked cyclodextrin metal organic framework. The preparation method comprises the following steps: mixing and dissolving ibuprofen and gamma-cyclodextrin in potassium hydroxide, filtering, evaporating and diffusing methanol into the solution, carrying out primary crystallization, taking a certain volume of the reacted solution, adding cetyltrimethylammonium bromide and methanol into the reacted solution, carrying out secondary crystallization, and drying to obtain the ibuprofen-gamma-cyclodextrin compound. And preparing the CD-MOFs loaded with the ibuprofen. And then dissolving the CD-MOFs loaded with the ibuprofen in a DMF (Dimethyl Formamide) solvent, and adding a cross-linking agent, namely isophorone diisocyanate, so as to prepare the CL-CD-MOFs loaded with the ibuprofen. The cross-linked cyclodextrin metal organic framework disclosed by the invention can load ibuprofen, stably exists in water, delays drug release, and provides reference for preparing an ibuprofen oral liquid preparation with a slow-release effect..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Dez. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
LI MENGLU [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-15, Last update posted on www.tib.eu: 2024-03-13, Last updated: 2024-03-22 |
|---|
| Patentnummer: |
CN117224702 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA000557757 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA000557757 | ||
| 003 | DE-627 | ||
| 005 | 20240322142203.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240315s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA000557757 | ||
| 035 | |a (EPA)CN117224702 | ||
| 035 | |a (EPA)89082092 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a LI MENGLU |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Crosslinked cyclodextrin metal organic framework capable of loading ibuprofen and preparation method thereof |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-12-15, Last update posted on www.tib.eu: 2024-03-13, Last updated: 2024-03-22 | ||
| 520 | |a The invention provides a cross-linked cyclodextrin metal organic framework capable of loading ibuprofen and a preparation method of the cross-linked cyclodextrin metal organic framework. The preparation method comprises the following steps: mixing and dissolving ibuprofen and gamma-cyclodextrin in potassium hydroxide, filtering, evaporating and diffusing methanol into the solution, carrying out primary crystallization, taking a certain volume of the reacted solution, adding cetyltrimethylammonium bromide and methanol into the reacted solution, carrying out secondary crystallization, and drying to obtain the ibuprofen-gamma-cyclodextrin compound. And preparing the CD-MOFs loaded with the ibuprofen. And then dissolving the CD-MOFs loaded with the ibuprofen in a DMF (Dimethyl Formamide) solvent, and adding a cross-linking agent, namely isophorone diisocyanate, so as to prepare the CL-CD-MOFs loaded with the ibuprofen. The cross-linked cyclodextrin metal organic framework disclosed by the invention can load ibuprofen, stably exists in water, delays drug release, and provides reference for preparing an ibuprofen oral liquid preparation with a slow-release effect. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a C08G: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture c12p) | |
| 650 | 4 | |a cet | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a LIANG XIAOMEI |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 15. Dez. |
| 773 | 1 | 8 | |g year:2023 |g day:15 |g month:12 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/89082092/publication/CN117224702A1?q=CN117224702 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 15 |c 12 | ||