Universal DNA sensing tool box for cell surface as well as preparation method and application of universal DNA sensing tool box
The invention discloses a cell surface universal DNA sensing tool box as well as a preparation method and application thereof, and belongs to the technical field of DNA nanotechnology. The DNA sensing tool box comprises a DNA origami frame, and further comprises a sensing core and an anchoring module which are respectively assembled on the inner surface and the outer surface of the DNA origami frame. The invention discloses a cell surface universal sensing tool box based on a DNA origami framework, in which an anchoring module and a sensing core can be replaced according to different experiment requirements, and a highly customized platform for controlling the cell state is constructed. The platform is anchored on the surface of a cell in a non-covalent or covalent binding manner, a nano mechanical-natural hybrid cell is constructed, the cell is endowed with the capability of sensing an unconventional signal, the diversity of cell function regulation is expanded, and a new strategy is provided for diagnosis and treatment application of engineering cells and bacteria..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 15. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
YE BANGCE [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-15, Last update posted on www.tib.eu: 2024-04-08, Last updated: 2024-04-15 |
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| Patentnummer: |
CN117224672 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000557455 |
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| 520 | |a The invention discloses a cell surface universal DNA sensing tool box as well as a preparation method and application thereof, and belongs to the technical field of DNA nanotechnology. The DNA sensing tool box comprises a DNA origami frame, and further comprises a sensing core and an anchoring module which are respectively assembled on the inner surface and the outer surface of the DNA origami frame. The invention discloses a cell surface universal sensing tool box based on a DNA origami framework, in which an anchoring module and a sensing core can be replaced according to different experiment requirements, and a highly customized platform for controlling the cell state is constructed. The platform is anchored on the surface of a cell in a non-covalent or covalent binding manner, a nano mechanical-natural hybrid cell is constructed, the cell is endowed with the capability of sensing an unconventional signal, the diversity of cell function regulation is expanded, and a new strategy is provided for diagnosis and treatment application of engineering cells and bacteria. | ||
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