Small organic molecule capable of being activated by alkaline phosphatase and visible light as well as preparation method and application of small organic molecule
The invention discloses a small organic molecule capable of being activated by alkaline phosphatase and visible light as well as a preparation method and application of the small organic molecule. The structural formula of the small organic molecule is as shown in formula I in the specification. The small organic molecule and the cis-trans isomer thereof exist in a stable cis-form or trans-form configuration under the dark condition and have no cytotoxicity. Under the irradiation of visible light, small organic molecules are subjected to cis-trans isomerization, and the isomerization efficiency is regulated and controlled by the concentration of serum albumin in the environment. On the basis, visible light with good biocompatibility and albumin widely existing in an organism can be used as dual regulation and control means, so that small organic molecules have no toxic or side effect under the physiological condition of high-serum albumin. In a tumor cell environment, through visible light irradiation and albumin concentration removal, small organic molecules are in a trans-configuration, and through alkaline phosphatase reaction, efficient tumor cell killing ability is exerted, drug activity is controlled in time and space, and the drug has an application prospect in on-demand precise treatment of tumors. # imgabs0 #.
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 03. Okt. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
ZHANG DEQING [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-10-03, Last update posted on www.tib.eu: 2024-03-12, Last updated: 2024-03-15 |
|---|
| Patentnummer: |
CN116836196 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA000498475 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA000498475 | ||
| 003 | DE-627 | ||
| 005 | 20240315101449.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240315s2023 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA000498475 | ||
| 035 | |a (EPA)CN116836196 | ||
| 035 | |a (EPA)88158594 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a ZHANG DEQING |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Small organic molecule capable of being activated by alkaline phosphatase and visible light as well as preparation method and application of small organic molecule |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2023-10-03, Last update posted on www.tib.eu: 2024-03-12, Last updated: 2024-03-15 | ||
| 520 | |a The invention discloses a small organic molecule capable of being activated by alkaline phosphatase and visible light as well as a preparation method and application of the small organic molecule. The structural formula of the small organic molecule is as shown in formula I in the specification. The small organic molecule and the cis-trans isomer thereof exist in a stable cis-form or trans-form configuration under the dark condition and have no cytotoxicity. Under the irradiation of visible light, small organic molecules are subjected to cis-trans isomerization, and the isomerization efficiency is regulated and controlled by the concentration of serum albumin in the environment. On the basis, visible light with good biocompatibility and albumin widely existing in an organism can be used as dual regulation and control means, so that small organic molecules have no toxic or side effect under the physiological condition of high-serum albumin. In a tumor cell environment, through visible light irradiation and albumin concentration removal, small organic molecules are in a trans-configuration, and through alkaline phosphatase reaction, efficient tumor cell killing ability is exerted, drug activity is controlled in time and space, and the drug has an application prospect in on-demand precise treatment of tumors. # imgabs0 # | ||
| 650 | 4 | |a C07F: Acyclic, carbocyclic, or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium (metal-containing porphyrins c07d0487220000;macromolecular compounds c08) | |
| 650 | 4 | |a bio | |
| 650 | 4 | |a C12P: Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a C07C: Acyclic or carbocyclic compounds (macromolecular compounds c08;production of organic compounds by electrolysis or electrophoresis c25b0003000000, c25b0007000000) | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a HUANG YANYAN |4 aut | |
| 700 | 0 | |a ZHAN CHI |4 aut | |
| 700 | 0 | |a YANG YANG |4 aut | |
| 700 | 0 | |a ZHANG GUANXIN |4 aut | |
| 700 | 0 | |a ZHAO RUI |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2023) vom: 03. Okt. |
| 773 | 1 | 8 | |g year:2023 |g day:03 |g month:10 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/88158594/publication/CN116836196A1?q=CN116836196 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 03 |c 10 | ||