ANTIBODY AND USE THEREOF
Provided are an antibody or an antigen-binding fragment thereof and the use thereof. The antibody or the antigen-binding fragment thereof contains a CDR sequence selected from at least one of the following: the CDR sequence of a heavy chain variable region as shown in SEQ ID NOs: 1-3 and the CDR sequence of a light chain variable region as shown in SEQ ID NOs: 4-6. The antibody can effectively bind to an α3 domain of MICCA or MICB, can further promote the binding of NKG2D to MICCA and/or MICB, can effectively treat or prevent MICCA and/or MICB-mediated diseases, and can promote the NK cells in killing tumors..
| Medienart: |
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Patent| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Europäisches Patentamt - (2024) vom: 22. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
TIAN ZHIGANG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-02-22, Last update posted on www.tib.eu: 2024-04-22, Last updated: 2024-04-26 |
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| Patentnummer: |
AU2022428620 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000477893 |
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| 520 | |a Provided are an antibody or an antigen-binding fragment thereof and the use thereof. The antibody or the antigen-binding fragment thereof contains a CDR sequence selected from at least one of the following: the CDR sequence of a heavy chain variable region as shown in SEQ ID NOs: 1-3 and the CDR sequence of a light chain variable region as shown in SEQ ID NOs: 4-6. The antibody can effectively bind to an α3 domain of MICCA or MICB, can further promote the binding of NKG2D to MICCA and/or MICB, can effectively treat or prevent MICCA and/or MICB-mediated diseases, and can promote the NK cells in killing tumors. | ||
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| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a G01N: Investigating or analysing materials by determining their chemical or physical properties (measuring or testing processes other than immunoassay, involving enzymes or microorganisms c12m, c12q) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000) | |
| 650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
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