TARGETED THERAPIES IN CANCER
The disclosure provides methods to categorize cancers and cancer patients using a classifier, TME Panel-1, which stratifies patients and cancers according to tumor microenvironments. Treatment decisions are then guided by the presence/absence of a particular TME phenotype class. Also provided are methods for treating a subject, e.g., a human subject, afflicted with gastric cancer, breast cancer, prostate cancer, liver cancer, carcinoma of head and neck, melanoma, colorectal cancer, or ovarian cancer comprising administering a particular therapy depending on the classification of the cancer's TME according to the TME Panel-1 classifier. Also provided are personalized treatments that can be administered to patients depending on the TME Panel-1 classification of a particular type of cancer, e.g., left or right colorectal cancer or dMMR colorectal cancer..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 02. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
BENJAMIN LAURA E [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-11-02, Last update posted on www.tib.eu: 2024-04-24, Last updated: 2024-04-26 |
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| Patentnummer: |
WO2022204438 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000280720 |
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| 520 | |a The disclosure provides methods to categorize cancers and cancer patients using a classifier, TME Panel-1, which stratifies patients and cancers according to tumor microenvironments. Treatment decisions are then guided by the presence/absence of a particular TME phenotype class. Also provided are methods for treating a subject, e.g., a human subject, afflicted with gastric cancer, breast cancer, prostate cancer, liver cancer, carcinoma of head and neck, melanoma, colorectal cancer, or ovarian cancer comprising administering a particular therapy depending on the classification of the cancer's TME according to the TME Panel-1 classifier. Also provided are personalized treatments that can be administered to patients depending on the TME Panel-1 classification of a particular type of cancer, e.g., left or right colorectal cancer or dMMR colorectal cancer. | ||
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