Polydopamine-coated calcium peroxide drug-loaded nanosphere as well as preparation method and application thereof
The invention discloses a polydopamine-coated calcium peroxide drug-loaded nanosphere as well as a preparation method and application thereof. The preparation method comprises the following steps: dispersing an inorganic matter calcium salt in a methanol solution of a template agent, adjusting the pH value and stirring, adding an H2O2 solution, and centrifuging, washing and drying after stirring to obtain a calcium peroxide nanosphere; dispersing the calcium peroxide nanospheres in an ethanol solution to obtain a calcium peroxide nanosphere dispersion system; under the stirring condition, adding a dopamine hydrochloride aqueous solution into the calcium peroxide nanosphere dispersion system, then adding an aqueous solution containing chemotherapeutic drugs, adjusting the pH value to 7-8, and stirring for 12-24 hours in a dark place; and centrifuging, washing and drying to obtain the drug-loaded nanospheres with calcium peroxide coated with polydopamine. The polydopamine-coated calcium peroxide drug-loaded nanospheres obtained by the method have the characteristics of good biocompatibility and biodegradability and capability of being combined with light photothermal, and can realize treatment of superficial tumors..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 26. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
HUI JUNFENG [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-26, Last update posted on www.tib.eu: 2024-03-13, Last updated: 2024-03-22 |
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| Patentnummer: |
CN117281794 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000268542 |
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| 245 | 1 | 0 | |a Polydopamine-coated calcium peroxide drug-loaded nanosphere as well as preparation method and application thereof |
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| 520 | |a The invention discloses a polydopamine-coated calcium peroxide drug-loaded nanosphere as well as a preparation method and application thereof. The preparation method comprises the following steps: dispersing an inorganic matter calcium salt in a methanol solution of a template agent, adjusting the pH value and stirring, adding an H2O2 solution, and centrifuging, washing and drying after stirring to obtain a calcium peroxide nanosphere; dispersing the calcium peroxide nanospheres in an ethanol solution to obtain a calcium peroxide nanosphere dispersion system; under the stirring condition, adding a dopamine hydrochloride aqueous solution into the calcium peroxide nanosphere dispersion system, then adding an aqueous solution containing chemotherapeutic drugs, adjusting the pH value to 7-8, and stirring for 12-24 hours in a dark place; and centrifuging, washing and drying to obtain the drug-loaded nanospheres with calcium peroxide coated with polydopamine. The polydopamine-coated calcium peroxide drug-loaded nanospheres obtained by the method have the characteristics of good biocompatibility and biodegradability and capability of being combined with light photothermal, and can realize treatment of superficial tumors. | ||
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
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