COMPOUNDS FOR PROGRAMMABLE PROTEIN DEGRADATION AND METHODS OF USE FOR THE DISEASE TREATMENT
Compounds of Formula (IA) (Targeting Moiety)-(Linker)-(Protease Ligand) (IA), where the targeting moiety is an oligonucleotide capable of binding a target protein and the protease ligand is a ligand capable of binding a protease, and methods for the use thereof are provided. Also provided are compounds of Formula (IB) (Targeting Moiety)-(Linker)-(Protease Ligand or E3 Ligase Ligand) (IB), where the targeting moiety is an oligonucleotide capable of binding a target protein, the protease ligand is a ligand capable of binding a protease, and the E3 ligase ligand is a ligand capable of binding an E3 ligase, and methods for the use thereof are provided..
Medienart: |
Patent |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Europäisches Patentamt - (2024) vom: 03. Jan. Zur Gesamtaufnahme - year:2024 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
HUANG HAOJIE [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
Sonstige Themen: |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2024-01-03, Last update posted on www.tib.eu: 2024-03-14, Last updated: 2024-03-22 |
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Patentnummer: |
EP4297792 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA000250406 |
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520 | |a Compounds of Formula (IA) (Targeting Moiety)-(Linker)-(Protease Ligand) (IA), where the targeting moiety is an oligonucleotide capable of binding a target protein and the protease ligand is a ligand capable of binding a protease, and methods for the use thereof are provided. Also provided are compounds of Formula (IB) (Targeting Moiety)-(Linker)-(Protease Ligand or E3 Ligase Ligand) (IB), where the targeting moiety is an oligonucleotide capable of binding a target protein, the protease ligand is a ligand capable of binding a protease, and the E3 ligase ligand is a ligand capable of binding an E3 ligase, and methods for the use thereof are provided. | ||
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