Application of combination of miltinib amine butantriol and PD-L1 antibody in preparation of medicine for treating melanoma
The invention relates to the field of biological medicine, in particular to application of combination of miltinib amine butantriol and a PD-L1 antibody in preparation of a medicine for treating melanoma. The application shows that the miltinib amine butantriol can reduce pyroptosis, enhance the antigen presentation function of macrophages and dendritic cells, weaken the immunosuppression function of bone marrow-derived suppressive cells, enhance the function of effector CD8 + T cells and improve the anti-tumor immune response, thereby improving the survival of mice with melanoma..
Medienart: |
Patent |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Europäisches Patentamt - (2023) vom: 08. Dez. Zur Gesamtaufnahme - year:2023 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
YANG SHUO [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
Sonstige Themen: |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-08, Last update posted on www.tib.eu: 2024-03-13, Last updated: 2024-03-22 |
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Patentnummer: |
CN117180289 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA000127248 |
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520 | |a The invention relates to the field of biological medicine, in particular to application of combination of miltinib amine butantriol and a PD-L1 antibody in preparation of a medicine for treating melanoma. The application shows that the miltinib amine butantriol can reduce pyroptosis, enhance the antigen presentation function of macrophages and dendritic cells, weaken the immunosuppression function of bone marrow-derived suppressive cells, enhance the function of effector CD8 + T cells and improve the anti-tumor immune response, thereby improving the survival of mice with melanoma. | ||
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