Cell penetrating peptide conjugates and methods of use thereof
Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded to the oligonucleotide or linked by a linker, the peptide comprising at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, with the proviso that the peptide comprises 7 to 40 amino acid residues in total and does not comprise any artificial amino acid residues; the oligonucleotide comprises a total of 12 to 40 contiguous nucleobases, wherein at least 12 contiguous nucleobases are complementary to a target sequence in the human dystrophin gene..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 26. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WOOD MATTHEW [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-12-26, Last update posted on www.tib.eu: 2024-04-22, Last updated: 2024-04-26 |
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| Patentnummer: |
CN117295525 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA000100730 |
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| 520 | |a Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded to the oligonucleotide or linked by a linker, the peptide comprising at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, with the proviso that the peptide comprises 7 to 40 amino acid residues in total and does not comprise any artificial amino acid residues; the oligonucleotide comprises a total of 12 to 40 contiguous nucleobases, wherein at least 12 contiguous nucleobases are complementary to a target sequence in the human dystrophin gene. | ||
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