The link between moderate COVID-19 and delayed manifestation of glomerulonephritis: Insights from cluster analysis of TGF-β1 and VEGF levels
Recent data reveal delayed pathological kidney changes occurring 8-12 months post-moderate COVID-19, often detected for the first time. While severe COVID-19 leads to interstitial and subsequent glomerular lesions, the predominant changes in moderate cases remain elusive. This study aimed to investigate the potential association between moderate COVID-19 and the manifestation of glomerulonephritis (GN). Methods. This cross-sectional study included 25 patients with stage 1-2 GN and a history of moderate COVID-19 8-12 months before the onset of GN, 27 individuals without GN who experienced COVID-19, and 20 healthy subjects without a history of COVID-19. Transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) levels in blood and urine were measured using enzyme-linked immunosorbent assay. Cluster and classification data mining methods were utilized for these markers to assess potential relationships between moderate COVID-19 and GN manifestation. Results. A significant increase in blood and urine TGF-β1 and VEGF levels was found in GN patients with a history of moderate COVID-19 (p<0.05), while elevated blood VEGF was observed in those without GN (p<0.05). Cluster analysis affirmed the correlation, emphasizing that urinary TGF-β1 within the range of 1.352 to 5.693 pg/ml and urinary VEGF < 214.12 pg/ml serve as classification rules for predicting GN. Conclusions. The cluster and classification analysis method for TGF-β1 and VEGF levels can be utilized in clinical practice to predict the development of GN in the long-term post-COVID period..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Український Журнал Нефрології та Діалізу - (2024), 1(81) |
| Sprache: |
Englisch ; Russisch ; Ukrainisch |
|---|
| Beteiligte Personen: |
L.O. Zub [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.31450/ukrjnd.1(81).2024.05 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ09719784X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ09719784X | ||
| 003 | DE-627 | ||
| 005 | 20240413174700.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240413s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.31450/ukrjnd.1(81).2024.05 |2 doi | |
| 035 | |a (DE-627)DOAJ09719784X | ||
| 035 | |a (DE-599)DOAJ22320e7f994f49d18eb607d3b5519ef9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng |a rus |a ukr | ||
| 050 | 0 | |a RC870-923 | |
| 100 | 0 | |a L.O. Zub |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The link between moderate COVID-19 and delayed manifestation of glomerulonephritis: Insights from cluster analysis of TGF-β1 and VEGF levels |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Recent data reveal delayed pathological kidney changes occurring 8-12 months post-moderate COVID-19, often detected for the first time. While severe COVID-19 leads to interstitial and subsequent glomerular lesions, the predominant changes in moderate cases remain elusive. This study aimed to investigate the potential association between moderate COVID-19 and the manifestation of glomerulonephritis (GN). Methods. This cross-sectional study included 25 patients with stage 1-2 GN and a history of moderate COVID-19 8-12 months before the onset of GN, 27 individuals without GN who experienced COVID-19, and 20 healthy subjects without a history of COVID-19. Transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) levels in blood and urine were measured using enzyme-linked immunosorbent assay. Cluster and classification data mining methods were utilized for these markers to assess potential relationships between moderate COVID-19 and GN manifestation. Results. A significant increase in blood and urine TGF-β1 and VEGF levels was found in GN patients with a history of moderate COVID-19 (p<0.05), while elevated blood VEGF was observed in those without GN (p<0.05). Cluster analysis affirmed the correlation, emphasizing that urinary TGF-β1 within the range of 1.352 to 5.693 pg/ml and urinary VEGF < 214.12 pg/ml serve as classification rules for predicting GN. Conclusions. The cluster and classification analysis method for TGF-β1 and VEGF levels can be utilized in clinical practice to predict the development of GN in the long-term post-COVID period. | ||
| 653 | 0 | |a Diseases of the genitourinary system. Urology | |
| 700 | 0 | |a B.V. Horban |e verfasserin |4 aut | |
| 700 | 0 | |a V.T. Kulachek |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Український Журнал Нефрології та Діалізу |d State Institution «Institute of Nephrology NAMS of Ukraine", 2018 |g (2024), 1(81) |w (DE-627)DOAJ000141488 |x 26167352 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g number:1(81) |
| 856 | 4 | 0 | |u https://doi.org/10.31450/ukrjnd.1(81).2024.05 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/22320e7f994f49d18eb607d3b5519ef9 |z kostenfrei |
| 856 | 4 | 0 | |u https://ukrjnd.com.ua/index.php/journal/article/view/830 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2304-0238 |y Journal toc |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2616-7352 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |j 2024 |e 1(81) | ||