Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study
Introduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU). Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Türkiye. All adult patients (<18 years) hospitalized in ICUs and developed candidemia between 01.01.2020- 31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared. Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer’s and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals. Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
---|---|
Enthalten in: |
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi - 28(2023), 3, Seite 456-465 |
Sprache: |
Englisch ; Türkisch |
---|
Beteiligte Personen: |
Taliha Karakök [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
Candidemia |
---|
doi: |
10.5578/flora.20239716 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ095086110 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ095086110 | ||
003 | DE-627 | ||
005 | 20240413091049.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240413s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.5578/flora.20239716 |2 doi | |
035 | |a (DE-627)DOAJ095086110 | ||
035 | |a (DE-599)DOAJ6281f59066984eacb5f9be9dfc48f33f | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng |a tur | ||
050 | 0 | |a RC109-216 | |
050 | 0 | |a QR1-502 | |
100 | 0 | |a Taliha Karakök |e verfasserin |4 aut | |
245 | 1 | 0 | |a Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Introduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU). Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Türkiye. All adult patients (<18 years) hospitalized in ICUs and developed candidemia between 01.01.2020- 31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared. Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer’s and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals. Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken. | ||
650 | 4 | |a candidemia | |
650 | 4 | |a covid-19 | |
650 | 4 | |a risk factors | |
650 | 4 | |a intensive care unit | |
653 | 0 | |a Infectious and parasitic diseases | |
653 | 0 | |a Microbiology | |
700 | 0 | |a Melih Gaffar Gözükara |e verfasserin |4 aut | |
700 | 0 | |a Yeşim Uygun Kızmaz |e verfasserin |4 aut | |
700 | 0 | |a Yakup Demir |e verfasserin |4 aut | |
700 | 0 | |a Melike Törüyenler Coşkunpınar |e verfasserin |4 aut | |
700 | 0 | |a Şerife Altun Demircan |e verfasserin |4 aut | |
700 | 0 | |a Yusuf Arslan |e verfasserin |4 aut | |
700 | 0 | |a Pelin İlkören |e verfasserin |4 aut | |
700 | 0 | |a Eda Alp Göker |e verfasserin |4 aut | |
700 | 0 | |a Ahmet Doğan |e verfasserin |4 aut | |
700 | 0 | |a Türkan Tüzün |e verfasserin |4 aut | |
700 | 0 | |a Şükran Sevim |e verfasserin |4 aut | |
700 | 0 | |a Yasemin Çakır |e verfasserin |4 aut | |
700 | 0 | |a Mehmet Emirhan Işık |e verfasserin |4 aut | |
700 | 0 | |a Çiğdem Mermutluoğlu |e verfasserin |4 aut | |
700 | 0 | |a Alpay Azap |e verfasserin |4 aut | |
700 | 0 | |a Sami Kınıklı |e verfasserin |4 aut | |
700 | 0 | |a Süda Tekin |e verfasserin |4 aut | |
700 | 0 | |a Serap Şimşek Yavuz |e verfasserin |4 aut | |
700 | 0 | |a Sedef Zeliha Öner |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |d Bilimsel Tip Yayinevi, 2018 |g 28(2023), 3, Seite 456-465 |w (DE-627)DOAJ000080411 |x 1300932X |7 nnns |
773 | 1 | 8 | |g volume:28 |g year:2023 |g number:3 |g pages:456-465 |
856 | 4 | 0 | |u https://doi.org/10.5578/flora.20239716 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/6281f59066984eacb5f9be9dfc48f33f |z kostenfrei |
856 | 4 | 0 | |u http://www.floradergisi.org/managete/fu_folder/2023-03/2023-28-03-456-465.pdf |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1300-932X |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
951 | |a AR | ||
952 | |d 28 |j 2023 |e 3 |h 456-465 |