Autoimmune bullous disorder flares following severe acute respiratory syndrome coronavirus 2 vaccination: a case series
Abstract Background Autoimmune bullous disorders develop due to autoantibodies targeting intercellular adhesion proteins of hemidesmosomes and desmosomes and may be triggered by viral infections and vaccines. Recent reports suggest that the coronavirus disease 2019 vaccination may trigger flares or exacerbations of preexisting autoimmune diseases, including new onset autoimmune bullous disorders. There are less data on whether vaccination against severe acute respiratory syndrome coronavirus 2 may also exacerbate preexisting autoimmune bullous disorders. Case presentation Here we present three cases, two white males (ages 69 years and 88 years) with bullous pemphigoid and one white 50-year-old female with pemphigus foliaceus, wherein all individuals developed minor, tractable flares of their preexisting autoimmune bullous disorders after receiving the coronavirus disease 2019 vaccination, which were readily treatable with topical or low-dose systemic corticosteroids. Conclusions Dermatologists managing patients with autoimmune bullous disorders should be cognizant of the uncommon potential for flares of the disorder following vaccination for severe acute respiratory syndrome coronavirus 2. Flares of bullous pemphigoid and pemphigus foliaceus following vaccination for severe acute respiratory syndrome coronavirus 2 in these cases were mild and tractable..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
|---|---|
| Enthalten in: |
Journal of Medical Case Reports - 17(2023), 1, Seite 6 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cody J. Rasner [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
Autoimmune |
|---|
| doi: |
10.1186/s13256-023-04146-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ091841402 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ091841402 | ||
| 003 | DE-627 | ||
| 005 | 20240414143857.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240412s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13256-023-04146-y |2 doi | |
| 035 | |a (DE-627)DOAJ091841402 | ||
| 035 | |a (DE-599)DOAJ0af128d7a470460caed259c6f763296e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a Cody J. Rasner |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autoimmune bullous disorder flares following severe acute respiratory syndrome coronavirus 2 vaccination: a case series |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Background Autoimmune bullous disorders develop due to autoantibodies targeting intercellular adhesion proteins of hemidesmosomes and desmosomes and may be triggered by viral infections and vaccines. Recent reports suggest that the coronavirus disease 2019 vaccination may trigger flares or exacerbations of preexisting autoimmune diseases, including new onset autoimmune bullous disorders. There are less data on whether vaccination against severe acute respiratory syndrome coronavirus 2 may also exacerbate preexisting autoimmune bullous disorders. Case presentation Here we present three cases, two white males (ages 69 years and 88 years) with bullous pemphigoid and one white 50-year-old female with pemphigus foliaceus, wherein all individuals developed minor, tractable flares of their preexisting autoimmune bullous disorders after receiving the coronavirus disease 2019 vaccination, which were readily treatable with topical or low-dose systemic corticosteroids. Conclusions Dermatologists managing patients with autoimmune bullous disorders should be cognizant of the uncommon potential for flares of the disorder following vaccination for severe acute respiratory syndrome coronavirus 2. Flares of bullous pemphigoid and pemphigus foliaceus following vaccination for severe acute respiratory syndrome coronavirus 2 in these cases were mild and tractable. | ||
| 650 | 4 | |a Bullous pemphigoid | |
| 650 | 4 | |a Pemphigus | |
| 650 | 4 | |a COVID | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a Vaccination | |
| 650 | 4 | |a Autoimmune | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 700 | 0 | |a Brittney Schultz |e verfasserin |4 aut | |
| 700 | 0 | |a Kimberly Bohjanen |e verfasserin |4 aut | |
| 700 | 0 | |a David R. Pearson |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t Journal of Medical Case Reports |d BMC, 2010 |g 17(2023), 1, Seite 6 |w (DE-627)DOAJ000049131 |x 17521947 |7 nnns |
| 773 | 1 | 8 | |g volume:17 |g year:2023 |g number:1 |g pages:6 |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13256-023-04146-y |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/0af128d7a470460caed259c6f763296e |z kostenfrei |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13256-023-04146-y |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1752-1947 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 17 |j 2023 |e 1 |h 6 | ||