The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens
Abstract The coinfection of ALVs (ALV-J plus ALV-A or/and ALV-B) has played an important role in the incidence of tumors recently found in China in local breeds of yellow chickens. The study aims to obtain a better knowledge of the function and relevance of ALV coinfection in the clinical disease of avian leukosis, as well as its unique effect on the pathogenicity in Three-yellow chickens. One-day-old Three-yellow chicks (one day old) were infected with ALV-A, ALV-B, and ALV-J mono-infections, as well as ALV-A + J, ALV-B + J, and ALV-A + B + J coinfections, via intraperitoneal injection, and the chicks were then grown in isolators until they were 15 weeks old. The parameters, including the suppression of body weight gain, immune organ weight, viremia, histopathological changes and tumor incidence, were observed and compared with those of the uninfected control birds. The results demonstrated that coinfection with ALVs could induce more serious suppression of body weight gain (P < 0.05), damage to immune organs (P < 0.05) and higher tumor incidences than monoinfection, with triple infection producing the highest pathogenicity. The emergence of visible tumors and viremia occurred faster in the coinfected birds than in the monoinfected birds. These findings demonstrated that ALV coinfection resulted in considerably severe pathogenic and immunosuppressive consequences..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
|---|---|
| Enthalten in: |
BMC Veterinary Research - 20(2024), 1, Seite 6 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Peikun Wang [VerfasserIn] |
|---|
| Links: |
doi.org [kostenfrei] |
|---|
| Themen: |
Avian leukosis virus |
|---|
| doi: |
10.1186/s12917-024-03896-1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
DOAJ09119492X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ09119492X | ||
| 003 | DE-627 | ||
| 005 | 20240414051846.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240412s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12917-024-03896-1 |2 doi | |
| 035 | |a (DE-627)DOAJ09119492X | ||
| 035 | |a (DE-599)DOAJ301674f5c37c47c9a703105f28212bc0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a SF600-1100 | |
| 100 | 0 | |a Peikun Wang |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The coinfection of ALVs causes severe pathogenicity in Three-Yellow chickens |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The coinfection of ALVs (ALV-J plus ALV-A or/and ALV-B) has played an important role in the incidence of tumors recently found in China in local breeds of yellow chickens. The study aims to obtain a better knowledge of the function and relevance of ALV coinfection in the clinical disease of avian leukosis, as well as its unique effect on the pathogenicity in Three-yellow chickens. One-day-old Three-yellow chicks (one day old) were infected with ALV-A, ALV-B, and ALV-J mono-infections, as well as ALV-A + J, ALV-B + J, and ALV-A + B + J coinfections, via intraperitoneal injection, and the chicks were then grown in isolators until they were 15 weeks old. The parameters, including the suppression of body weight gain, immune organ weight, viremia, histopathological changes and tumor incidence, were observed and compared with those of the uninfected control birds. The results demonstrated that coinfection with ALVs could induce more serious suppression of body weight gain (P < 0.05), damage to immune organs (P < 0.05) and higher tumor incidences than monoinfection, with triple infection producing the highest pathogenicity. The emergence of visible tumors and viremia occurred faster in the coinfected birds than in the monoinfected birds. These findings demonstrated that ALV coinfection resulted in considerably severe pathogenic and immunosuppressive consequences. | ||
| 650 | 4 | |a Coinfection | |
| 650 | 4 | |a Monoinfection | |
| 650 | 4 | |a Avian leukosis virus | |
| 650 | 4 | |a Pathogenicity | |
| 650 | 4 | |a Three-yellow chickens | |
| 653 | 0 | |a Veterinary medicine | |
| 700 | 0 | |a Jing Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Na Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Cong Xue |e verfasserin |4 aut | |
| 700 | 0 | |a Zhaoqing Han |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t BMC Veterinary Research |d BMC, 2005 |g 20(2024), 1, Seite 6 |w (DE-627)DOAJ00009207X |x 17466148 |7 nnns |
| 773 | 1 | 8 | |g volume:20 |g year:2024 |g number:1 |g pages:6 |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s12917-024-03896-1 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/301674f5c37c47c9a703105f28212bc0 |z kostenfrei |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s12917-024-03896-1 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/1746-6148 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 951 | |a AR | ||
| 952 | |d 20 |j 2024 |e 1 |h 6 | ||